血必净联合乌司他丁与单用乌司他丁治疗脓毒症的Meta分析 |
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引用本文: | 李倩,任杰,刘国恩.血必净联合乌司他丁与单用乌司他丁治疗脓毒症的Meta分析[J].中国药物经济学,2014(10):9-13. |
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作者姓名: | 李倩 任杰 刘国恩 |
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作者单位: | 中国药科大学国际医药商学院;中国卫生经济研究中心 |
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摘 要: | 目的:探讨血必净注射液对炎症的影响及治疗脓毒症患者的临床疗效。方法检索各大数据库,查找血必净治疗脓毒症的相关临床试验,并采用RevMan 5.0进行Meta分析。结果共纳入4项随机对照临床试验,治疗组181例患者给予血必净+乌司他丁+基础治疗,对照组181例患者给予乌司他丁+基础治疗。Meta分析结果显示,治疗组患者与对照组患者的肿瘤坏死因子(TNF-α)水平比较,差异无统计学意义(WMD=-5.16,95% CI:-11.0~0.76);治疗组患者与对照组患者在白细胞介素-6(IL-6)水平(WMD=-57.82,95%CI:-112.12~-3.52)、降钙素原(PCT)水平(WMD=-0.53,95%CI:-0.88~-0.19)、平均住院时间(WMD=-3.63,95%CI:-4.68~-2.58)、平均机械通气时间(WMD=-3.77,95%CI:-4.70~-2.83)比较,差异均有统计学意义。结论应用血必净患者的白细胞介素-6(IL-6)、前降钙素(PCT)水平更低,平均住院时间、平均机械通气时间更短。
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关 键 词: | 血必净 乌司他丁 脓毒症 Meta分析 |
Meta-Analysis of Xuebijing in Treating Sepsis |
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Institution: | Qian Li;Jie Ren;Gordon Liu; |
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Abstract: | Objective To know the efficacy of Xuebijing injection for the treatment of sepsis.Methods Literatures of RCT(randomized control ed trial) or CCT (clinical control ed trial) were selected to Meta-analysis.Results Four RCTs were included,with 181 patients in the treatment group were given Xuebijing+Ulinastatin+based treatment,181 patients in the control group were given Ulinastatin+basic treatment.Meta-analysis showed that the tumor necrosis factor(TNF-a)levels (WMD = -5.16,95% CI:-11.07~0.76)of experimental group and the control group were not statistical y different,but the interleukin(IL-6) levels(WMD=-57.82,95% CI:-112.12~-3.52),the procalcitonin(PCT) (WMD=-0.53,95% CI:-0.88~-0.19)levels,the average length of stay(WMD=-3.63,95% CI:-4.68~-2.58)and the average duration of mechanical ventilationWMD=-3.77,95% CI (-4.70,-2.83)]of the treatment group and the control group were statistical y different.Conclusion Current results indicated that the application of Xuebijing injection for the treatment of sepsis provided a lower level of IL-6 and PCT,a shorter length of stay and duration of mechanical ventilation. |
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Keywords: | Xuebijing Ulinastatin Sepsis Meta Analysis |
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