尤特奇RS-PO/RL-PO制备缓释片的工艺研究

比较尤特奇RS-PO和RL-PO的缓释性能,为更好地应用提供依据.以荼碱为模型药物,选用尤特奇RS-PO,RL-PO为缓释材料,制备了茶碱骨架缓释片和包衣缓释片,通过体外释放度试验考察尤特奇RS-PO和RL-PO的缓释性能.结果表明,RS-PO的阻滞作用较强,不宜单独作为骨架缓释材料使用；RL-PO的缓释作用强,对药物...

Technical study on sustained release tablets preparation of Eudragit RS-PO/RL-PO

For better application of Eudragit RS-PO and RL-PO,the sustained release properties are compared.Using theophylline as a model drug and Eudragit RS-PO and RL-PO as sustained release materials for preparation of theophyline sustained release tablets and coated sustained released tablets,Eudragit RS-PO and RL-PO release properties are tested through in vitro release test.RS-PO has a relatively strong retard property,which is not recommended to be used alone as a skeleton sustained-release material.RL-PO is co...