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| 6-APA溶液物理化学特性的测定 | |
| 引用本文： | 王鹏辉,马文婵,曹维峰.6-APA溶液物理化学特性的测定[J].价值工程,2011,30(18):277-278. |
| 作者姓名： | 王鹏辉 马文婵 曹维峰 |
| 作者单位： | 1. 石药集团河北中润制药有限公司,石家庄,050041 2. 石药集团河北中润制药有限公司,石家庄050041;河北工业大学,天津300130 3. 石药集团内蒙古信汇制药有限公司,呼和浩特,010206 |
| 基金项目： | 科技部科技支撑项目资助;项目编号2007BAI266B00，国家863项目资助;项目编号2006AA020305 |
| 摘 要： | 6-氨基青霉烷酸(6-APA)是青霉素的母核,是半合成β-内酞胺抗生素生产的重要中间体。本文对于6-APA的溶液物理化学特性进行了分析与测定,其中包括溶解度、密度、粘度数据等,为6-APA工业化设计提供了依据。 |
| 关 键 词： | 6-APA 溶液 特性 |
Determination of the Physical and Chemical Properties of 6-APA Solutions |
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| Wang Penghui,Ma Wenchan,Cao Weifeng.Determination of the Physical and Chemical Properties of 6-APA Solutions[J].Value Engineering,2011,30(18):277-278. | |
| Authors: | Wang Penghui Ma Wenchan Cao Weifeng |
| Institution: | Wang Penghui; Ma Wenchan; Cao Weifeng( (1)Shijiazhuang Pharm Group Hebei Zhongrun Pharmaceutical CO., LTD, Shijiazhuang 050041, China; (2)Hebei University of Technology, Tianjin 300130, China ; (3)Shijiazhuang Pharm Group Nei Monggol Xinhui Pharmaceutical CO., LTD, Hohhot 010206, China ) |
| Abstract: | 6-aminopenicillanic acid （6-APA）is the nucleus of the penicillin molecule and serves as an important inteImediate in the production of semisynthetie β-1actam antibiotics. This paper study the crystallization thermodynamic data, such as solubility, metastable zone and other basic data of 6-APA were measured based on experiments, which are useful for design and control of production of 6-APA. |
| Keywords: | 6-aminopenilillanie acid solution features |
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