|
|||||
|
|
| 力影响下的IGF-1剪切变体——力生长因子(MGF)研究进展 | |
| 引用本文： | 王峰,赵建芳,王宝珍,王贵平.力影响下的IGF-1剪切变体——力生长因子(MGF)研究进展[J].价值工程,2011,30(1):202-203. |
| 作者姓名： | 王峰 赵建芳 王宝珍 王贵平 |
| 作者单位： | 1. 河北师范大学体育学院,石家庄,050016 2. 石家庄职业技术学院公体部,石家庄,050081 3. 河北省南和县第三中学,南和,054401 |
| 摘 要： | 力生长因子(MGF)作为IGF-1的一个剪切变构体,能够响应力信号刺激而调节自身的表达,进而影响局部组织和结构变化,如肌肉肥大、骨骼强壮等。研究表明,MGF能够激活卫星细胞、促进干细胞增殖,在治疗肌肉丢失、预防心肌损伤、防止细胞凋亡和修复神经损伤以及治疗骨缺陷等方面具有重要的作用,因此对MGF深入研究,期望在疾病治疗和组织工程修复领域取得广泛的应用。 |
| 关 键 词： | IGF-1 MGF 卫星细胞 |
Study on Splice Variant of Insulin-like Growth Factor-1:Mechano Growth Factor(MGF)under Influence of Force |
|
| Wang Feng,Zhao Jianfang,Wang Baozhen,Wang Guiping.Study on Splice Variant of Insulin-like Growth Factor-1:Mechano Growth Factor(MGF)under Influence of Force[J].Value Engineering,2011,30(1):202-203. | |
| Authors: | Wang Feng Zhao Jianfang Wang Baozhen Wang Guiping |
| Institution: | ① Wang Feng;② Zhao Jianfang;② Wang Baozhen;③ Wang Guiping(①School of Physical Education,Hebei Normal University,Shijiazhuang 050016,China; ②Public Sport Department,ShiJiaZhuang Vocational Technology Institute,Shijiazhuang 050081,China; ③Nanhe No.3 Middle School of Hebei Province,Nanhe 054401,China) |
| Abstract: | The mechano growth factor （MGF） as an splice variant of the insulin-like growth factor-1, which can respond to the stimulation of force signal and adjust expression of itself, and then influence local mass and structure changes, for instance muscle hypertrophy, strength skeleton etc. Studies have shown that the MGF can activate satellite cells and enhancement multiplication of stein cells. It plays an important role on cure sarcopenia, prevent myocardial damage and apoptosis, repair of nerve injury＂ and the treatment of bone defects ect. Therefore, making an intensive study of MGF will be widely used in treat disease and repair tissue engineering. |
| Keywords: | IGF-1 MGF |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |