含左氧氟沙星抗结核方案对耐多药肺结核患者痰培养转阴率的影响

目的探讨含左氧氟沙星抗结核方案对耐多药肺结核(MDR-TB)患者痰培养转阴率的影响。方法选取2017年2月至2019年2月锦州市传染病医院收治的62例MDR-TB患者作为研究对象,按随机数字表法分为对照组与观察组,各31例。对照组行常规2HRZE/4HR化疗方案,观察组在对照组治疗基础上采用左氧氟沙星治疗,比较两组治疗结果。结果观察组治疗1、3、6个月后痰菌转阴率分别为80.65%、83.87%、90.32%,高于对照组56.67%、58.06%、67.74%(P<0.05);观察组病灶吸收治疗有效率为93.55%,高于对照组74.19%(P<0.05);观察组不良反应发生率为19.35%,与对照组16.13%比较,差异无统计学意义(P>0.05)。结论含左氧氟沙星抗结核方案在MDR-TB患者中应用效果理想,可提高痰菌转阴率及病灶吸收率,且不会增加过多不良反应,安全性较高。

Effect of Levofloxacin-Containing Anti-Tuberculosis Program on the Negative Rate of Sputum Culture in Patients with Multi-Drug-Resistant Tuberculosis

Objective To explore the effect of levofloxacin-containing anti-tuberculosis program on the negative rate of sputum culture in patients with multidrug-resistant tuberculosis. Methods A total of 62 patients with multi-drug-resistant tuberculosis admitted to the 7th Department of Internal Medicine, Jinzhou Infectious Disease Hospitalfrom February 2017 to February 2019 were selected as the research objects and were divided into an observation group and a control group according to random number table, with 31 cases in each group. The control group received conventional 2HRZE/4HR chemotherapy, and the observation group was treated with levofloxacin plus conventional 2HRZE/4HR chemotherapy. The treatment results of the 2 groups were compared. Results The negative rates of sputum bacteria in the observation group after 1, 3, and 6 months of treatment were 80.65%, 83.87%, and 90.32%, respectively, which were higher than those of the control group(56.67%, 58.06%, and 67.74%)(P<0.05);the total effective rate of lesion absorption in the observation group was 93.55%, which was higher than 74.19% in the control group(P<0.05);the incidence of adverse reactions in the observation group was 19.35%, and there was no significant difference compared with 16.13% in the control group(P>0.05). Conclusion The anti-tuberculosis regimen containing levofloxacin has an ideal application effect in patients with multidrug-resistant tuberculosis. It can increase the rate of sputum bacteria conversion and the absorption rate of lesions, and will not increase too many adverse reactions. It is safe and worthy of application.