| 别嘌醇分散片制备工艺研究 |
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| 引用本文： | 钟仲,李荣敏,何鸿玲,麦蕴华. 别嘌醇分散片制备工艺研究[J]. 中国药物经济学, 2021, 0(3): 120-124 |
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| 作者姓名： | 钟仲 李荣敏 何鸿玲 麦蕴华 |
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| 作者单位： | 佛山市禅城区人民医院药械科;增城市中医医院药剂科;广州中医药大学中药学院 |
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| 基金项目： | 广东省佛山市科技创新项目(医学类科技攻关)(1920001000634)。 |
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| 摘 要： | 目的 优选别嘌醇分散片的制备工艺,提高药物的生物利用度和临床疗效.方法 本实验采用紫外分光光度法分别考察别嘌醇与不同辅料混合压片后的溶出速率,确定最适合的辅料进行分散片制备.结果 筛选出最优制备处方:以微晶纤维素(MCC):乳糖=3:2作为填充剂,交联聚维酮(PVPP)6％作为崩解剂,滑石粉3％作为润滑剂.结论 该制备...
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| 关 键 词： | 别嘌醇 分散片 紫外分光光度法 崩解剂 交联聚维酮 |
Study on Preparation of Allopurinol Dispersible Tablets |
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| ZHONG Zhong,LI Rong-Min,HE Hong-Ling,MAI Yun-Hua. Study on Preparation of Allopurinol Dispersible Tablets[J]. China Journal of Pharmaceutical Economics, 2021, 0(3): 120-124 |
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| Authors: | ZHONG Zhong LI Rong-Min HE Hong-Ling MAI Yun-Hua |
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| Affiliation: | (Department of Pharmacy and Medical Equipment,Chancheng District People's Hospital in Foshan City,Guangdong Province,Foshan 528000,China;Department of Pharmacy,Zengcheng Hospital of Traditional Chinese medicine,Guangzhou 511300,China;College of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective The preparation process of Allopurinol dispersible tablets was optimized to improve the bioavailability and clinical efficacy of the drug. Methods In this study, the dissolution rate of allopurinol mixed with different excipients was investigated by UV Spectrophotometer, and the best excipients were selected to prepare the dispersible tablets. Results The optimal formula consists of 3∶2 of MCC and lactose, 6% PVPP, and 3% talcum powder. Conclusion The preparation process can improve the bioavailability of the drug and is reasonable and feasible. |
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| Keywords: | Allopurinol Dispersible tablets UV Spectrophotometer Disintegrant PVPP |
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