多奈哌齐联合盐酸美金刚、高压氧治疗血管性认知障碍患者的临床效果

目的探讨多奈哌齐联合盐酸美金刚、高压氧治疗血管性认知障碍患者的临床效果。方法选取2018年10月至2020年5月于沈阳市第一人民医院就诊的血管性认知障碍患者116例作为研究对象,按照治疗方案不同分为对照组与试验组,对照组采取多奈哌齐联合盐酸美金刚治疗,试验组在此基础上给予高压氧治疗。根据蒙特利尔认知评估量表(MoCA)对两组患者治疗前后的认知功能进行评价,比较两组患者的基质金属蛋白酶-9(MMP-9)和基质金属蛋白酶组织抑制因子-1(TIMP-1),采用简易智力状态检查量表(MMSE)和日常生活活动能力量表(ADL)对患者的精神状态和日常生活能力进行评价。结果两组患者治疗前MoCA评分比较,差异无统计学意义(P>0.05);治疗后,两组MoCA评分升高,且试验组MoCA评分高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前MMP-9和TIMP-1比较,差异无统计学意义(P>0.05);治疗后,两组患者MMP-9和TIMP-1降低,且试验组两项指标低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前MMSE与ADL比较,差异无统计学意义(P>0.05);治疗后,两组患者MMSE、ADL升高,且试验组两项指标高于对照组,差异有统计学意义(P<0.05)。结论使用多奈哌齐联合美金刚、高压氧治疗血管性认知障碍,能有效改善患者的认知功能、精神状态和日常生活能力,疗效确切。

Clinical Effect Analysis of Donepezil Combined with Membrance and Hyperbaric Oxygen in the Treatment of Patients with Vascular Cognitive Impairment

Objective To explore the clinical effect of donepezil combined with membrance and hyperbaric oxygen in the treatment of patients with vascular cognitive impairment. Methods A total of 116 patients with vascular cognitive impairment admitted to Shenyang First People’s Hospital from October 2018 to May 2020 were selected as the research objects and were divided into a control group and an observation group according to different treatment regimens. The control group was treated with donepezil and memantine, and experimental group was given hyperbaric oxygen therapy plus donepezil and memantine. According to the Montreal Cognitive Assessment Scale(MoCA), the cognitive function of the 2 groups of patients before and after treatment was evaluated, and the matrix metalloproteinase-9(MMP-9) and tissue inhibitor of matrix metalloproteinase-1(TIMP-1), the Simple Mental State Examination Scale(MMSE) and the Activity of Daily Living Scale(ADL) were used to evaluate the patient’s mental state and ability of daily living. Results There was no significant difference in the MoCA scores of the 2 groups before treatment(P>0.05);after treatment, the MoCA scores of the 2 groups increased, and the MoCA score of the test group was higher than that of the control group, the difference was statistically significant(P<0.05). The comparison of MMP-9 and TIMP-1 between the 2 groups of patients before treatment was not statistically significant(P>0.05);after treatment, MMP-9 and TIMP-1 in the 2 groups of patients decreased, and the two indexes of the test group were lower than those of the control group, the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference between MMSE and ADL between the 2 groups of patients(P>0.05);after treatment, the MMSE and ADL of the 2 groups of patients increased, and the 2 indexes of the test group were higher than those of the control group, the difference was statistically significant(P<0.05). Conclusion The use of donepezil combined with memantine and hyperbaric oxygen in the treatment of vascular cognitive impairment can effectively improve the patient’s cognitive function, mental state and ability of daily living, with definite curative effect.