妊娠末期糖尿病患者应用格列本脲联合胰岛素治疗的效果及对妊娠结局与新生儿指标的影响

目的 探讨妊娠末期糖尿病患者应用格列本脲联合胰岛素治疗的效果及对妊娠结局与新生儿指标的影响.方法 选取盘锦辽油宝石花医院2017年1月至2019年6月收治的妊娠末期糖尿病患者150例作为研究对象,将其遵照双盲随机法分为对照组(75例,采用单纯胰岛素治疗方式)与试验组(75例,采用格列本脲联合胰岛素治疗方式).比较两组基...

Effect of Glibenclamide Combined with Insulin in the Treatment of Patients with Gestational Diabetes Mellitus and Its Influence on Pregnancy Outcome and Neonatal Indicators

Objective To explore the effect of glibenclamide combined with insulin in the treatment of patients with gestational diabetes mellitus and its influence on pregnancy outcome and neonatal indicators. Methods A total of 150 patients with gestational diabetes mellitus admitted to Liaoyou Baoshihua Hospital from January 2017 to June 2019 were selected as the research objects and were randomly divided into a control group(75 cases, treated only with insulin therapy) and an experimental group(75 cases, treated with glibenclamide combined with insulin). The basic data, FPG, 2 hPG, HBA1C levels, pregnancy outcomes and neonatal indicators were compared between the 2 groups. Results Compared with the control group, the FPG, 2 hPG and HBA1C levels of the experimental group were lower, and the differences were statistically significant(P<0.05). Compared with the control group, the weight, body length, head circumference, and shoulder circumference of the newborns in the experimental group were better, and the difference was statistically significant(P<0.05);compared with the control group, the preterm birth rate, hypoglycemia rate and jaundice rate of the experimental group were lower, and the difference was statistically significant(P<0.05). Conclusion The application of glibenclamide combined with insulin therapy in patients with end-stage diabetes mellitus is beneficial to control the blood glucose level of patients, improve the pregnancy outcome and neonatal indicators, with significant curative effect.