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Weighted rank statistics in factorial designs with fixed effects
Authors:Edgar Brunner  Sebastian Domhof  & Madan L Puri
Institution:University of Göttingen, Department of Medical Statistics, Germany,;Indiana University, U.S.A.
Abstract:Nonparametric methods for the analysis of factorial designs with two fixed factors are considered. The sample sizes may be unequal and the distribution functions are not assumed to be continuous. Nonparametric hypotheses for the main effects and for the interaction are tested by ranking procedures where the statistics are weighted according to the different sample sizes within the levels of one factor. Simulations show that the approximations by the limiting normal distribution and by the t - and F -distributions are quite accurate if the samples sizes within the cells are at least 7 for all treatment combinations. Moreover, it turns out that the power for the weighted statistics is much higher than for the unweighted statistics. The application of the suggested procedures is demonstrated by the analysis of a data set from a clinical trial with ordered categorical data.
Keywords:ordered categorical data  multi-center clinical trials  nonparametric hypotheses
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