| 离子液中合成香豆素-3-羧酸乙酯的研究 |
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| 引用本文： | 宗乾收,冯利霞,缪程平.离子液中合成香豆素-3-羧酸乙酯的研究[J].嘉兴学院学报,2010,22(3):47-50. |
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| 作者姓名： | 宗乾收 冯利霞 缪程平 |
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| 作者单位： | 嘉兴学院生物与化学工程学院,浙江嘉兴,314001 |
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| 基金项目： | 嘉兴学院科研启动基金，浙江省自然科学基金 |
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| 摘 要： | 研究了在1-丁基-3-甲基咪唑四氟硼酸Bmim]BF4离子液中,用水杨醛和丙二酸二乙酯在二乙胺催化下制备香豆素-3-羧酸乙酯的反应.得出香豆素-3-羧酸乙酯的最佳制备工艺条件及收率为:n(水杨醛):n(丙二酸二乙酯)＝1.0:1.3,催化剂二乙胺用量为0.2mL(以2mL水杨醛计);香豆素-3-羧酸乙酯的收率为88.3%.同时还测定了该目标产物的熔点和红外光谱.
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| 关 键 词： | Knoevenage缩合反应 离子液 香豆素-3-羧酸乙酯 |
Synthesis of Ethyl Coumarin-3-carboxylate in Ionic Liquids |
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| ZONG Qian-shou,FENG Li-xia,MIAO Cheng-ping.Synthesis of Ethyl Coumarin-3-carboxylate in Ionic Liquids[J].Journal of Jiaxing College,2010,22(3):47-50. |
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| Authors: | ZONG Qian-shou FENG Li-xia MIAO Cheng-ping |
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| Institution: | ZONG Qian-shou,FENG Li-xia,MIAO Cheng-ping (School of Biological , Chemical Engineering,Jiaxing University,Jiaxing,Zhejiang 314001) |
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| Abstract: | Ethyl coumarin-3-carboxylate was synthesized from salicylaldehyde and diethyl malonate in 1-Butyl-3-methylimidazolium tetrafluoroborate ionic liquids (Bmim]BF4) by Knoevenagel condensation reaction using diethylamine as the catalyst. The optimum reaction conditions were: n(salicylaldehyde )/n( diethyl malonate) = 1.0:1.3,amount of diethylamine 0.2 mL (based on 2 mLof salicylaldehyde) and reaction time = 2h. Under the optimum conditions,the yield of ethyl coumarin-3-car-boxylate was 88. 3% . The products we... |
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| Keywords: | Knoevenagel condensation reaction ionic liquids ethyl coumarin-3-carboxylate |
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