Analysis of variance on indirectly measured variables

Abstract  When observations from a normal distribution can only be obtained indirectly by counting the number of subjects responding to a previously chosen dose, parameter estimates can be obtained by using probit analysis. Well-known is the maximum likelihood technique of parameter estimation, less known is the approach by weighted least squares. The latter approach is followed to compare the parameters of several normal distributions by testing their equality, in analogy with the analysis of variance. A practical situation gave rise to this study and it is worked out at the end of the paper.