碳酸二甲酯和邻苯二酚合成愈创木酚的研究

用邻苯二酚和碳酸二甲酯直接进行甲基化反应合成愈创木酚,对几种不同催化剂的性能进行了对比,并考察了原料配比、反应温度、碱性介质、催化剂对反应的影响。结果表明:按物质的量比n(邻苯二酚) n(碳酸二甲酯)=1 3投料、在150℃下反应、应用HY分子筛为催化剂,邻苯二酚的转化率可达37.6%。

Synthesis of Guaiacol with Dimethyl Carbonate and Catechol

Guaiacol is an impotant chemical intermediate which is widely used in pharmaceutical, perfumery and food flavoring industries. It was synthesized mainly from o-methoxyaniline. But it required a careful control of the reaction conditions and the yield was very low. In this paper, giaiacol was synthized with DMC and catechol. During the process, it was evaluated that the impaction of different catalyzers and some other reaction conditions. The best condition to synthesis guaiacol was when the ratio between catechol and DMC at 1∶3, the temperature at 150 ℃ by using HY molecular sieve as catalyzer. The transformation efficiency of catechol could reach 37.6%.