TEMPO催化体系在糖伯羟基氧化中的应用进展

介绍了近年来TEMPO体系在催化氧化构建糖醛酸方面的研究进展，分别简述了TEMPO/次氯酸盐、TEMPO/BAIB体系、其他TEMPO/共氧化剂体系以及TEMPO/过渡金属/有氧催化体系的基本原理，分析了它们的应用范围，并进一步比较了4种TEMPO体系氧化糖伯羟基为糖醛酸的反应机制、底物适用范围以及优缺点。分析表明，通过TEMPO催化氧化，可解决传统工艺中使用重金属氧化剂所面临的环境污染等问题。基于此，对其发展前景进行了展望，指出今后可在以下方面对TEMPO氧化展开深入研究：1）开展TEMPO/次氯酸盐氧化工艺研究，避免或减少无机盐的引入，降低对产品纯度的影响以及工业废盐对环境的污染；2）深入探索TEMPO/BAIB组合中溶剂体系的优化问题，为实现绿色清洁生产提供依据；3）对新兴的TEMPO有氧氧化体系进行系统、深入研究，以期实现在糖醛酸氧化上的应用推广。

Progress in the application of TEMPO catalytic system in the oxidationof the primary alcohol of saccharides

The research progress of TEMPO system in the construction of uronic acid by catalytic oxidation in recent years was introduced in this paper,the basic principles of TEMPO/hypochlorite,TEMPO/BAIB system,other TEMPO/co-oxidant systems and TEMPO/transition metal/aerobic system were briefly described,and their application scope was analyzed.Then,the reaction mechanism,application scope of substrates and advantages and disadvantages of the four TEMPO oxidation systems of primary hydroxyl to uronic acid were further compared.The analysis shows that TEMPO catalytic oxidation can solve the problems of environmental pollution faced by heavy metal oxidants in traditional processes.Based on this,the development outlook is prospected,and it is pointed out that TEMPO oxidation can be further studied in the following aspects in the future.1) It is essential to carry out the TEMPO/hypochlorite oxidation process research in the aim of avoiding or reducing the introduction of inorganic salts,reducing the adverse effect on product purity and industrial waste salt pollution to the environment;2) Further studies to optimize the solvent system in TEMPO/BAIB combination should be performed so as to provide basis for the realization of green and clean production;3) Systematical and intensive research of the emerging TEMPO aerobic oxidation system should be investigated in order to realize its application and promotion in the uronic acid oxidation.