| 正交试验法优选超临界CO2流体萃取丹参中丹参酮工艺的研究 |
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| 引用本文： | 常虹飞,杨 震.正交试验法优选超临界CO2流体萃取丹参中丹参酮工艺的研究[J].河北工业科技,2008,25(6):352-353,360. |
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| 作者姓名： | 常虹飞 杨 震 |
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| 作者单位： | 石药集团维生药业有限公司,河北石家庄,050051 |
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| 摘 要： | 研究了超临界CO2流体萃取法萃取丹参中丹参酮的最佳工艺条件,以丹参酮ⅡA含量为指标,用高效液相色谱法测定,采用L9(34)正交试验法对丹参中丹参酮的提取工艺进行优选。结果表明,萃取压力对萃取结果影响最为显著,最佳萃取压力为25 MPa,萃取温度为40℃,无水乙醇用量为30%(质量分数),萃取时间为2 h。
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| 关 键 词： | 丹参 丹参酮ⅡA 正交试验 超临界萃取 |
| 收稿时间： | 2008/4/12 0:00:00 |
| 修稿时间： | 2008/8/30 0:00:00 |
Study on orthogonal design for optimizing supercritical-CO2fluid extractiontechnique of tanshinones from radixs salviae |
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| CHANG Hong-fei and YANG Zhen.Study on orthogonal design for optimizing supercritical-CO2fluid extractiontechnique of tanshinones from radixs salviae[J].Hebei Journal of Industrial Science & Technology,2008,25(6):352-353,360. |
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| Authors: | CHANG Hong-fei and YANG Zhen |
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| Institution: | CHANG Hong-fei,YANG Zhen(Shijiazhuang Weisheng Pharmaceutical Company Limited,Shijiazhang Pharmaceutical Group,Shijiazhuang Hebei 050051,China) |
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| Abstract: | The optimal supercritical-CO2 fluid extraction technique of extracting tanshinones from radix salviae is explored.The content of tanshinone ⅡA as inspecting marker was determined by HPLC.The experiment was carried out through L9(34) orthogonal design to optimize extraction method.Among all the 4 inspected factors,the extracting pressure affected the result most significantly.The optimal technique of extraction: extraction pressure at 25 MPa,extraction temperature at 40 ℃,the amount of the anhydrous EtOH at 30%,and extraction time as 2 h. |
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| Keywords: | radixs salviae tanshinone ⅡA orthogonal design supercritical-CO2 fluid extraction |
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