低分子肝素联合丹参注射液治疗早发型重度子前期效果评估

目的探讨低分子肝素与丹参注射液联合用药对早发型子前期(重度)的治疗效果。方法选取我院2008年10月至2012年10月诊断为重度子前期的患者共124例(孕龄在25～34周),随机平均分为四组,每组31例。第一组患者使用常规硫酸镁治疗,第二组患者使用硫酸镁加丹参注射液治疗,第三组患者使用硫酸镁加低分子肝素治疗,第四组患者使用硫酸镁、低分子肝素以及丹参注射液三种药物联合治疗,对比各组相关治疗结果的差异。结果第四组患者的孕龄延长时间和羊水量明显增加,脐动脉S/D值下降,新生儿体重明显增加,新生儿窒息率明显下降,与另外三组比较,差异有统计学意义(P<0.05)。同时第四组患者胎盘的重量有所增加,与第一组比较,差异有统计学意义(P<0.05),与另外两组比较差异无统计学意义。结论联合使用低分子肝素和丹参注射液在早发型的重度子前期治疗效果明显。

Evaluation of Low Molecular Weight Heparin combined with Danshen Injection in the Treatment of Early Severe Pre Eclampsia

Objective To explore the low molecular weight heparin combined with Danshen injection in treatment of early onset preeclampsia （severe） treatment ef ect.Methods Retrospective analysis was carried out in 124 patients with early hairstyle severe preeclampsia from October 2008 to October 2012.These patients,gestational age 25 to 35 weeks,were randomly divided into four groups,31 patients in each group.The first group is joined with magnesium sulfate.The second group is joined with magnesium sulfate and salvia miltiorrhiza injection.The third group is joined with magnesium sulfate and low molecular heparin calcium.The fourth group is joined with magnesium sulfate,low molecular heparin calcium and salvia miltiorrhiza injection.The results of four groups on newborn＇s body quality, amniotic fluid index,umbilical artery S/D ratio,gestational age time and neonatal asphyxia rate are compared to find out the better treatment.Results The newborn＇s body quality and amniotic fluid index of the fourth group increase significantly.The umbilical artery S/D ratio of the fourth group decreases greatly.The gestational age time of the fourth group prolong.The neonatal asphyxia rate of the fourth group significantly decreases.Compared with the other three groups,there are obvious dif erences（P〈0.05）.The placenta weight of the fourth group increase compared with the first group.There are obvious differences between the fourth group and the first group（P〈0.05）.Compared with the other two groups had no statistical difference.Conclusion Low molecular heparin calcium and salvia miltiorrhiza injection have synergy in the treatment of early hairstyle severe preeclampsia.The treatment effect of low molecular heparin calcium combined salvia miltiorrhiza injection is obvious.This method is worth vigorously promoting in the clinical practice.