非甾体抗炎药物联合氨基葡萄糖治疗膝骨性关节炎的临床研究

目的观察非甾体抗炎药物联合氨基葡萄糖治疗膝骨性关节炎的疗效及患者不良反应,探讨治疗骨性关节炎临床用药。方法选取本院80例临床诊断为膝骨性关节炎患者,按照随机分配原则分为非选择性非甾体抗炎药治疗组20例;COX-2非甾体抗炎药治疗组20例;非选择性非甾体抗炎药联合氨基葡萄糖治疗组20例;COX-2非甾体抗炎药联合氨基葡萄糖治疗组20例。分别于治疗6周后进行临床疗效评定并观察其不良反应,确定最佳用药方案。结果药物治疗6周后,四组患者的疗效经多组间检验差异有统计学意义（P〈0.05）,联合氨基葡萄糖治疗组患者疗效优于非联合氨基葡萄糖;COX-2非甾体抗炎药联合氨基葡萄糖治疗组临床缓解比率与非选择性非甾体抗炎药联合氨基葡萄糖治疗组比较差异有统计学意义（P〈0.05）。COX-2非甾体抗炎药联合氨基葡萄糖治疗组不良反应率与其它三组比较,差异有统计学意义（P〈0.05）。结论膝骨性关节炎使用COX-2非甾体抗炎药联合氨基葡萄糖治疗,能够显著缓解骨性关节炎患者的症状,疗效确切,不良反应少,患者耐受性好,避免了短期内复发的可能。

Clinical Study of Non-steroidal Anti-inflammatory Drugs Combined Glucosamine in the Treatment of Osteoarthritis of Knee Joint

Objective To observe the efficacy of Non-steroidal anti-inflammatory drugs combined glucosamine in the treatment of osteoarthritis of knee joint, and respectively joint analysis of two kinds of mode of administrationglucosamine capsules clinical studies on the of osteoarthritis efficacy and adverse reactions, to explore the clinical use of drugs to treat osteoarthritis. Methods By selecting a hospital clinically patients diagnosed with osteoarthritis of the knee, 80 cases was divided into four groups of 20 cases in accordance with the principle of random allocation Respectively, after 6 weeks, the patients have been clinical efficacy evaluation and observed the adverse reactions,in order to determine the best regimen Results After 6 weeks of therapy, the efficacy of four patients tested by the multi-group and their difference was statistically significant （P〈005）, which is suggested that in patients treated with combination of glucosamine more effective than non-union glucosamine.COX-2 non-steroidal anti-inflammatory drugs glucosamine combined treatment group, clinical remission rate and non-selective non-steroidal anti-inflammatory drug glucosamine combined treatment group difference was statistically significant （P〈0.05） COX-2 non-steroidal anti-inflammatory drug combination therapy group Glucosamine adverse reaction rates compared with the other three groups, the difference was statistically significant （P〈0.05） Conclusion Knee osteoarthritis using COX-2 non-steroidal anti-inflammatory drug combination of glucosamine therapy, can significantly alleviate the symptoms of osteoarthritis, and be less adverse reactions and well tolerated in patients, which is to be avoid short-term recurrence possible.