| LC-MS检测化妆品中糖皮质激素的不确定度研究 |
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| 引用本文： | 郑晨,郑利,杨天宇,赵玉兰. LC-MS检测化妆品中糖皮质激素的不确定度研究[J]. 检验检疫科学, 2009, 19(6): 45-49 |
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| 作者姓名： | 郑晨 郑利 杨天宇 赵玉兰 |
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| 作者单位： | 苏州出入境检验检疫局,江苏,苏州,215104 |
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| 摘 要： | 根据JJF1059-1999《测量不确定度评价与表示》对建立液相色谱-质谱测定方法的不确定度评定方式,对糖皮质激素的测定进行不确定度分析。通过对地塞米松测定过程建立数学模型,包括对称重、溶液配制等方面,其中在方法的不确定度评定过程中,应主要考虑不确定度贡献较大的分量,从而简化实验操作步骤,提高工作效率。通过对标准曲线、称量、标准溶液配制、实验人员、环境等因素引入的不确定度进行分析,置信区间为95%时,k=2,得出不确定度结果为UC=31.40mg/mL,地塞米松含量c=（397.45±32.66）mg/mL。
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| 关 键 词： | LC-MS 不确定度 化妆品 地塞米松 |
Evaluation of Uncertainty in Determination of Hormones in Cosmetics by LC-MS |
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| Zheng Chen,Zheng Li,Yang Tianyu,Zha Yulan. Evaluation of Uncertainty in Determination of Hormones in Cosmetics by LC-MS[J]. Inspection and Quarantine Science, 2009, 19(6): 45-49 |
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| Authors: | Zheng Chen Zheng Li Yang Tianyu Zha Yulan |
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| Affiliation: | Zheng Chen, Zheng Li, Yang Tianyu, Zha Yulan (Suzhou Entry- Exit Inspection and Quarantine Bureau, Suzhou, Jiangsu, 215104) |
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| Abstract: | In order to analyze sources and influencing factors of uncertainty of results in determination of Hormones in Cosmetics by Liquid Chromatography Tandem Mass Spe - ctrometry（ LC -MS）. Through establishment of mathematical model in the Measurement process, the sources of uncertainty was analysised accurately, then attain the standard uncertainty and expanded uncertainty for the determination of Hormones in Cosmetics was 397.45 ± 32. 66mg/mL. |
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| Keywords: | LC-MS |
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