| 美伐他汀提取工艺研究 |
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| 引用本文： | 王健,张雪霞,王淑华,王海燕,李晓露,张金娟,张丽. 美伐他汀提取工艺研究[J]. 河北工业科技, 2010, 27(1): 35-37,40 |
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| 作者姓名： | 王健 张雪霞 王淑华 王海燕 李晓露 张金娟 张丽 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,河北石家庄,050015;华北制药集团微生物药物国家工程研究中心,河北石家庄,050015;华北制药集团维尔康制药有限公司,河北石家庄,050031 |
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| 摘 要： | 研究从发酵液中提取美伐他汀的工艺条件。通过单因素实验确定了从美伐他汀发酵液中提取美伐他汀的最佳工艺条件。结果表明,醋酸丁酯作为提取溶剂时,其最佳工艺条件如下:提取温度为50℃,物料比(醋酸丁酯体积(mL):菌丝质量(g))为8:1,提取时间为3 h,闭环温度为70℃,闭环时间为6 h。本工艺简便,收率高,适用于工业化生产。
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| 关 键 词： | 美伐他汀 发酵液 提取 |
Study on process of mevastatin extraction |
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| WANG Jian,ZHANG Xue-xi,WANG Shu-hu,WANG Hai-yan,LI Xiao-lu,ZHANG Jin-juan and ZHANG Li. Study on process of mevastatin extraction[J]. Hebei Journal of Industrial Science & Technology, 2010, 27(1): 35-37,40 |
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| Authors: | WANG Jian ZHANG Xue-xi WANG Shu-hu WANG Hai-yan LI Xiao-lu ZHANG Jin-juan ZHANG Li |
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| Affiliation: | 1.New Drug Research and Development Company Limited;NCPC;Shijiazhuang Hebei 050015;China;2.National Microbial Medicine Engineering and Research Center;3.Welcome Pharmaceutical Company Limited;Shijiazhuang Hebei 050031;China |
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| Abstract: | The process conditions of mevastatin extraction from mevastatin fermentation are studied.Through single factor test,the optimal conditions are determined.The results show that butyl acetate as extracting solvent requires the best technology conditions:temperature 50 ℃,ratio(butyl acetate volume/mL:mycelium weight/g)8∶1,time of extracting 3 hours,temperature of ring closed 70 ℃,and time of ring closed 6 hours.This process is simple,of high yield,and suitable for industrial manufacture. |
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| Keywords: | mevastatin fermentation extraction |
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