| 三七总皂苷对痛风的干预 |
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| 引用本文： | 陆再华,张福康,杨妍华. 三七总皂苷对痛风的干预[J]. 中国药物经济学, 2013, 0(6): 27-28 |
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| 作者姓名： | 陆再华 张福康 杨妍华 |
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| 作者单位： | 江苏省常州市第七人民医院,江苏常州,213011 |
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| 基金项目： | 常州市科技计划项目血塞通(三七总皂苷)对痛风的治疗及对痛风炎症损伤的ICAM-1的表达，编号 |
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| 摘 要： | 目的本文以尿酸钠100μg mL-1诱导体外急性炎症模型,观察三七总皂苷对ICAM-1表达及内皮细胞凋亡的影响,探讨临床用于痛风的价值。方法采用2.5、5.0、10.0μg mL-1浓度的三七总皂苷进行预干预,实时定量PCR检测ICAM-1的基因表达,流式细胞仪测定细胞凋亡率。结果三七总皂苷组2.5、5.0、10.0μg mL-1明显抑制细胞凋亡（6.90±1.07）%,与模型组比较P〈0.01;能显著抑制ICAM-1基因的表达。结论三七总皂苷显著抑制炎症因子ICAM-1的表达及细胞凋亡。
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| 关 键 词： | 三七总皂苷 ICAM-1 痛风 |
PNS on Gout the Hntervention |
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| Lu Zaihua , Zhang Fukang , Yang Yanhua. PNS on Gout the Hntervention[J]. China Journal of Pharmaceutical Economics, 2013, 0(6): 27-28 |
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| Authors: | Lu Zaihua Zhang Fukang Yang Yanhua |
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| Affiliation: | Lu Zaihua;Zhang Fukang;Yang Yanhua; |
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| Abstract: | Objective In this paper,uric acid sodium 100μg mL-1induced acute inflammation model in vitro,to observe the effect of total saponins of three seven on ICAM-1 expression and apoptosis of endothelial cells,to investigate the clinical value of for ventilation.Methods The total saponins of three seven 2.5,5.0,10.0μg mL-1 concentration of pre intervention,expression of real-time quantitative PCR detection of ICAM-1 gene,cell apoptosis was detected by flow cytometry.Results Total saponins of three seven groups of 2.5,5.0,10.0μg mL-1significantly inhibited apoptosis（6.90±1.07）%,compared with model group,P〈0.01;expression can significantly inhibit ICAM-1 gene.Conclusion Total saponins three seven inhibited the cell apoptosis and expression of ICAM-1 cytokines. |
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| Keywords: | Total saponins three seven ICAM-1 Gout |
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