| 丁香苦苷 PLGA 纳米粒的体外释放研究 |
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| 引用本文： | 封文静,管庆霞,张亮,李梦雪,李永吉.丁香苦苷 PLGA 纳米粒的体外释放研究[J].黑龙江商学院学报,2014(4):395-397. |
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| 作者姓名： | 封文静 管庆霞 张亮 李梦雪 李永吉 |
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| 作者单位： | 黑龙江中医药大学,哈尔滨150040 |
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| 基金项目： | 国家自然基金面上项目（81274091） |
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| 摘 要： | 为研究丁香苦苷PLGA纳米粒（ SYR-NP）的体外释药规律，采用动态透析技术考察SYR-NP体外释药性能，并用高效液相测定SYR-NP和SYR溶液的含量，以累积释药百分率进行不同模型的拟合．SYR-NP的体外释放规律基本符合Higuchi方程的释药模型，拟合的释药动力学方程为 Q＝0．1281＋0．0189t1/2（r＝0．9568）．相比于药物溶液，SYR-NP具有良好的缓释的作用．
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| 关 键 词： | 丁香苦苷 PLGA纳米粒 体外释放 |
Study on release in vitro of Syringopicroside PLGA nanoparticles |
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| FENG Wen-jing,GUAN Qing-xia,ZHANG Liang,LI Meng-xue,LI Yong-ji.Study on release in vitro of Syringopicroside PLGA nanoparticles[J].Journal of Harbin Commercial University(Natural Sciences Edition),2014(4):395-397. |
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| Authors: | FENG Wen-jing GUAN Qing-xia ZHANG Liang LI Meng-xue LI Yong-ji |
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| Institution: | (Heilongjiang University of Chinese Medicine, Harbin 150040, China) |
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| Abstract: | In order to study the vitro release profile of Syringopicroside PLGA nanoparticles , the dynamic dialysis technology was employed to study the in vitro release ability of SYR -NP and Syringopicroside solution .The content of Syringopicroside was determined by HPLC , and the fitting of different models were performed based on the accumulative drug release percentages .The release curve of Syringopicroside PLGA nanoparticles was in line with Higuchi equation , Q=0.128 1＋0.018 9t1/2 （ r=0.956 8） .Compared with the Syringopi-croside solution , SYR-NP has a satisfactory sustained release effect . |
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| Keywords: | Syringopicroside PLGA nanoparticles：drug release in vitro |
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