The Competencies of Regions – Canada's Clusters in Biotechnology

Knowledge-intensive industries tend to concentrate geographically, because of the many spillovers that they generate. Thus new biotechnology firms often set up in regions that have innovative firms, government laboratories and universities, which attract them to enter. In this paper we unveil some of the characteristics of Canadian clusters in biotechnology: the key regions, their relative importance, and the main firms and government laboratories that attract new entrants. Moreover, we develop the concept of regions as nexus of competencies, a notion already put forward for firms, but that may be relevant to regions within nations and, ultimately, to nations as well. Capabilities of organizations and regions vary, and a thorough study of organizational and regional capabilities should precede the analysis of knowledge spillovers.Toronto is the main center of biotechnology in Canada, followed by Montreal, and Vancouver. The total population of the metropolitan area (a proxy for immediate market size and venture capital) explains the size, location and characteristics of most Canadian clusters. University research is also a key factor explaining the size of the biotechnology clusters, once population is held constant.Within nations, scientific and technical competencies vary strongly among regions. Some regions within countries concentrate a disproportionate share of the capabilities of all developed and developing nations. Moreover, regions tend to concentrate competencies on a few domains of expertise. This is what literature calls "agglomeration effects": companies active in the same field of technology tend to cluster geographically. They do so in order to share a common labor pool, and to obtain ready access to research institutions such as government laboratories and universities, or to key markets and customers, such as large assemblers or government facilities (Feldman et al., 1999). The specialized literature calls these institutions and key markets/customers "entry attractors" (Swan et al., 1998).In many types of science-based industries (SBIs), such as biotechnology, information technology and advanced materials, the major attractors are universities and government laboratories. In a few more mature SBIs, including aerospace and aircraft, large assemblers tend to naturally attract smaller producers of, components and specialized software.In this respect Canada is similar, to other nations (Niosi, 2000). Its competencies cluster around a few large and medium-sized urban agglomerations, such as Toronto, Montreal, Vancouver, Ottawa, Edmonton, and Calgary. Specialized clusters have also developed around smaller cities. This study builds a theory of the competencies of regions using biotechnology as a case study. Government laboratories, as well as universities and a few large firms, attract entry. The goal of the paper is to examine – using quantitative data – the relative competencies of regions in biotechnology, and the role of NRC laboratories and university research.     

Entry,Growth and Patenting in Industrial Clusters: A Study of the Aerospace Industry in the UK

This paper studies how firm performance is influenced by the strength of the industrial cluster (or industrial district) in which it is located. The paper presents estimates of firm-level employment and patent growth models for a range of '5-digit' aerospace industries in the UK. In these models, employment in the firm's own sector and employment in other sectors is taken as a measure of the strength of the cluster. Strong positive clustering effects are found in many sectors, but nevertheless some clustering effects are negative. Entry into clusters of this industry is also examined and some sectors are found to attract new entry while others are only attracted.     

Is the Creation and Development of Biotech SMEs Localised? Conclusions Drawn from the French Case

The article examines the localisation effects within biotechnology, concentrating in particular on the French case. The paper has two strands of analysis. The first presents a detailed statistical survey of the French biotechnology sector. Among other things, the survey shows that a) localisation effects within France are strong, b) in terms of dependence on local cluster infrastructures (especially universities and related public research institutes), most firms progress from an entry stage in which they are very dependent on local cluster infrastructures, to a mature phase in which their networks become more national/international in focus and c) French firms can be grouped into four general types of firms, ranging from "type 1" growth oriented product firms, to "type 2" niche market players, "type 3" subsidiaries of larger firms, and "type 4" firms that have been acquired. Localisation effects differ across these firms, esp. across type 1 (international) and type 2 (very localised) firms. The second strand of analysis consists of a review of the localisation and related cluster literature, with implications drawn out for localisation and knowledge spillovers within biotech clusters. It examines the relative effects of scientific centres proximity and compares them to the public policy of start-up creation.     

Service Industry Clustering: A Comparison of Broadcasting in Three City-Regions

Drawing from two major studies of clustering in the UK broadcasting industry, this paper finds compelling differences between clusters; differences which explain performance variation and provide strong implications for the extant literature and UK regional policy. The paper finds that (a) regional processes have been overplayed with the importance of both broader external connectivity and narrower local impacts of location underestimated; (b) the policy-makers' conception of a successful cluster underplays the importance of large hub firms; (c) national policy has been more effective than regional policy in promoting UK broadcasting clusters; and (d) policy-makers should not overlook traditional business support.     

Firm size and efficiency in the German mechanical engineering industry

Research usually finds a positive size-efficiency relationship, but few studies focus on sectors dominated by small and medium-sized firms (SMEs). This paper fills this gap by analyzing this relationship in the German mechanical engineering industry sector, which is both successful and increasingly dominated by SMEs. The analysis, using a large and representative dataset, finds that small and large firms are, on average, the most efficient ones, while medium-sized firms have, on average, the greatest inefficiencies. Thus, the size-efficiency relationship is U-shaped rather than monotonically increasing. Additionally, the analysis finds that companies with active owner(s) are significantly more efficient and that capital firms are less efficient than firms with personally liable owners. Being located in either East or West Germany has no effect.     

Evaluation of technical efficiency among entrant and incumbent firms in the Spanish retailing sector: The effects of deregulation from a regional perspective

This study analyzes the efficiency of entrant and incumbent firms in the 1995–2003 period, after a significant shift in the institutional environment of the retail sector occurred with the deregulation of opening hours carried out imposed by decree law 6/2000. It also analyzes the evolution of efficiency in relation to the entrance cohorts and to their geographical localization. The results obtained show that the effects of opening hours by decree law 2000 have perhaps been negative on the level of efficiency of the new firms. The increasing of the inefficiency of the firms is observed through the cohorts with more intensity starting from the year 2000, although in general the tendency of the efficiency is negative at global level. There have not been statistically significant differences between the incoming firms and the incumbent ones for both specialized and non-specialized sectors. Finally, notable intersectoral and intrasectoral differences of efficiency exist among Autonomous Communities (i.e. regions).     

Specialization versus diversity in Canadian technological development

In the new era of liberalized North American trade one of Canada's goals is export-led growth in technology intensive activities. Macro-economic data show that technology intensive specializations are developing but their international success is limited. One reason is that business spends less on R&D in Canada than in most OECD countries. Problems associated with macro data have prompted the use of survey-derived data listing the high-technology products of firms in order to define technological clusters. Most of the firms comprising each cluster are small: the distribution of large producers and R&D labs and the structure of clusters are discussed. Aggregate and micro data are used to establish the localization of technology intensive industry, especially in the Toronto metropolitan region. This is the largest concentration of technology intensive firms and the importance of services as markets and as sources of technology intensive products is established. The conclusion weighs the importance of specialization versus diversity, small firm entrepreneurship versus the importance of large firms, and metropolitan attraction for high-tech firms vs. the chances of medium-sized urban centres.     

Start-ups as drivers of market mobility: an analysis at the region–sector level for The Netherlands

Although recent literature suggests that competition among incumbent firms is caused by the entry of new firms, this relationship has not yet been tested directly. In this study a regression model is established in which a direct measure of competition among incumbent firms, the market mobility rate, is explained by start-up rates and control variables. The results show that the effect of start-ups on market mobility varies by sector. There is a strong positive relationship for industry sectors but an insignificant relationship for service sectors. These results suggest differences in the types of entry between sectors and in the roles start-ups play in different sectors.     

Analysing the link between export intensity,innovation and firm size in a science-based industry

The aim of this paper is to contribute to a better understanding of the relationship between export intensity, innovation and size in a particular technological setting: a science-based industry. Using a sample of 121 firms in the French biotechnology industry, we have found that firm size is not a determinant for innovation or for export intensity. However, the results show a positive and significant link between innovation and export intensity. Our findings open a new agenda for policy-makers when interpreting how they should promote innovation and exports in science-based firms.     

The effects of business–university alliances on innovative output and financial performance: a study of publicly traded biotechnology companies

Companies in the biotechnology industry face major challenges in developing and commercializing new products. Focusing on publicly traded biotechnology firms that are not members of university incubators or research parks, this paper argues that the links these companies develop with universities can have beneficial effects on a company's operations. Analysis of 2457 alliances undertaken by 147 biotechnology firms shows that companies with university linkages have lower research and development (R&D) expenses while having higher levels of innovative output. However, the results do not support the proposition that companies with university linkages achieve higher financial performance than similar firms without such linkages.     

Small firms and technological development in the food processing machinery industry: The case of pasta and other cereal derivative machines in Italy

This study about Italian producers of machines and plants for pasta, basic cereals, snacks and bread factories attempts to shed some light on the role played by small and medium-sized enterprises (SMEs) in the Italian industry. Even if the high diffusion of SMEs has positively affected the performance of Italian economy during the seventies and the eighties, the new trends of technological change and global competition are expected to be unfavourable to this category of enterprises in the nineties. The analyses of a significant sample of firms makes clear that the industry is in the middle of a positive restructuring process. The structure of this sector shows a division of labour based on deverticalization of production, and a process of internationalization focused on exports and not on direct investments or joint ventures abroad. Leading firms are following growth strategies by new investments and acquisitions. Finally, as far as technological change is concerned, there is a significant increase of process innovations, thanks to the use of electronic components.An earlier release of this paper was presented at 7th EARIE (European Association for Research in Industrial Economics) Annual Conference in Lisbon, September 2–4 1990. We thank all the participants for their comments and suggestions, in particular P. Dunne.     

Geographic cluster size and firm performance

We examine whether there are increasing returns to locating in clusters—a fundamental premise of agglomeration theory. This premise is worth exploring because a) it has infrequently been studied; b) recent evidence suggests that diseconomies of agglomeration change over time and may alter the payoffs to firms located in clusters; and c) recent evidence suggests that there may be negative returns to agglomeration. We examine firm payoffs to clustering in the biotechnology industry, and consider five different measures of performance. Our results lend support to the view that there are increasing returns to cluster size, but also suggest that diseconomies of agglomeration play an increasingly important role as clusters evolve. We believe these results help in reconciling previous findings.     

Knowledge and the Climate Change Issue: An Exploratory Study of Cluster and Extra-Cluster Effects

Climate change, while potentially impacting many industries, appears to have considerable significance to the wine industry. Yet little is known about how firms acquire knowledge and gain an understanding of climate change and its impacts. This study, exploratory in nature and studying firms from the wine-producing region of Tasmania, is one of the first in the management literature to use cluster theory to examine the climate change issue. Firms are predicted to exchange knowledge about climate change more readily with other firms internal to the sub-cluster than with those external to the sub-cluster. The hypothesis does not find support. The study also proposes that the different characteristics of knowledge can either increase or decrease their flows in and around clusters. Specifically, “public” knowledge about climate change is predicted to flow more freely than “private” knowledge about climate change. The hypothesis does not find support. Finally, firms are expected to acquire knowledge about climate change from sources other than cluster-entrenched firms, and in particular peak national industry bodies. The hypothesis finds partial support. A discussion of the findings is presented along with future research directions.     

Recent Trends in the Size Structure of Italian Manufacturing Firms

This paper analyses the re-emergence of small-scale production which has characterised the more recent phase of industrial development in Western countries, providing updated evidence about the phenomenon and focussing in particular the attention on Italy, where it has been assuming peculiar relevance.Data show that in the course of the '80s the main industrial European countries – with the notable exception of Germany – have experienced a further reduction in the average size of manufacturing firms, which was declining since the mid-'70s. Yet, in all of the countries concerned the increase of the relative "weight" in the employment shares of small enterprises is associated to an overall decline of employment levels in absolute numbers (smaller firm do not succeed in making up for the whole amount of job losses in the industrial sector).These trends appear particularly strong in the Italian manufacturing sector. In particular, a transition matrix drawn from a data-base of over 200,000 firms and data relative to birth and exit rates show that the rising importance of small firms in terms of employment (in particular within the range between 10 and 50 employees) has been linked to higher rates of growth with respect both to large enterprises and very small ones, as well as to a relatively higher "inertia" of their entry rates with respect to the latter. More specifically, data highlight a peculiarly low frequency of growing firms in the range including very small units (less than 5 employees); at the same time, such firms' exit rates do not show any tendency to be especially affected by the slowing down of economic activity in the late '80s.     

Exploring the relationship between the human resource management practices and growth in small service firms

This paper seeks to evaluate the relationship between the growth and the human resource management (HRM) practices of small service firms in catering to professional services and the retailing sectors in the UK. The paper reports and analyses the findings of 196 face-to-face structured interviews with small service business owners. Findings suggest that employee empowerment contributes to the sales growth of small firms in the different sectors of the service industry. The study also shows that employee training and recruitment through formal channels contribute to the sales growth of firms operating in the catering sector. This paper argues that contextual variables – the extent of the competition and the availability of the workforce – have a bearing on the HRM practices employed by small service businesses.     

Information Sources for New Ventures in the Turkish Clothing Export Industry

Recently "born global" firms have received considerable attention in the entrepreneurship and international business literature. Managers leading these new ventures typically face substantial resource constraints when seeking information critical to internationalization. This paper examines how the owner/operators of new ventures in the Turkish clothing export industry utilize their informal and formal social networks to acquire the information they need to export successfully. Field research and a survey of 250 Turkish clothing firm owners was conducted in Istanbul, Turkey to explore this issue. Findings indicate that informal social ties – particularly friends and family connections – are key sources of information for new-venture firm owners in this industry. Two formal organizations provide export information to entrepreneurs in the Turkish clothing industry, but only one was found to be easily accessible to new-venture firm owners: the Istanbul Textile and Clothing Exporters' Union (ITKIB). OLS regression results reveal that new venture firm owners' perceptions of ITKIB's importance can be explained by their perceived importance of various kinds of export-oriented information offered by this organization. In particular, perceived importance of export-law, market-research, and export-process information drive their perceptions of the importance of their ITKIB membership.     

Social networks and marketing cooperation in entrepreneurial clusters: An international comparative study

This research examines factors that influence the development of marketing cooperation among cluster-based firms in different regions in the world. Theorists have consistently demonstrated the role and importance of economic externalities, such as knowledge spillovers, within industrial clusters. Less research attention has been paid to the investigation of marketing-based externalities, though it has been suggested that these may also accrue from geographical agglomeration. The study focus is on the development of joint marketing activities between firms operating in a single industry sector, located in close proximity. The results suggest that social networking is important in facilitating inter-firm cooperation in marketing activities. The study also explores whether the levels of inter-firm cooperation differs between countries with distinctly different levels of social collectivism. Interestingly, this study finds few significant differences in marketing cooperation among cluster-based firms from Scotland and Chile.     

Labour productivity in M&As: industry sector vs. services sector

Due to the high failure rate of the mergers and acquisitions (M&A) strategy, this study raises the questions of whether the pre-M&A performances of the acquirer and the target could predict improvement in labour productivity in the post-M&A period. The study also conducted sector analysis by comparison between three groups of the sample: the industry sector M&As, the services sector M&As and the all sectors M&As. The study uses a sample of 394 public firms from 13 countries that were involved in M&As. The study highlights the differences between the sectors. Buying a larger target in the services sector may not hinder the labour productivity in the post-M&A period, while in the industry sector, it may end in a negative influence on labour productivity. The study also shows that the labour productivity is higher in the services sector compared to the labour productivity in the industry sector, particularly during the integration stage.     

Market power and systematic risk

This paper examines the relationship between market power variables and the systematic risk, beta, of a firm. The study controls for the effects of dividend policy, liquidity, and earnings growth. Market power is measured by firm size (both sales and assets), proportion of industry sales, and the industry's four-firm concentration ratio. The study finds only a weak relationship between individual firm market power and firm risk, but there is evidence of a strong negative relationship between industry concentration and the market risk of the firms in an industry. This indicates that firms in concentrated industries experience lower capital costs than firms in less-concentrated industries. The existence of limit pricing is suggested as an explanation for this finding.     

外商直接投资对工业行业内部的技术外溢

本文利用1995-1997,2000-2003年期间,中国工业36个行业的平行数据,使用固定效应模型和随机效应模型估计了FDI对工业行业内部的技术外溢,及影响技术外溢的因素。结果显示:在1995-1997年期间,FDI对我国工业行业内部有不显著正的技术外溢。技术差距较小、劳动密集型行业获得较大的技术外溢。在2000-2003年期间,FDI对工业行业内部有显著正的技术外溢。技术差距较大、资本密集型工业行业获得较大的技术外溢。因此,本文的政策含义是,工业行业的引资应偏重技术差距较大的资本密集型行业。