Imitation and innovation new biologics,biosimilars and biobetters

ABSTRACT

Biopharmaceutical drugs are the future of the pharmaceutical industry. The United States is the world leader in the development of new biopharmaceutical products. These original new drugs, numbering close to 200, are now losing patent protection and imitators from several countries are entering the markets of comparable drugs, called biosimilars. Some companies are improving the original product, and these drugs are called biobetters. Even among the producers of biosimilars one finds different strategies, and these are linked to different government regulations concerning the approval of these products. Some biosimilar companies are aiming at developed-country markets (North America, the European Union and Japan), while other producers are targeting emerging, less-regulated markets. This introduction will present the dynamic picture of an industry in transition. The paper has a double aim: discuss the fuzzy frontier between imitation and innovation, and track the new contours of the pharmaceutical industry.     

Higher education costs and scale and scope economies

Higher education multi-product cost functions are estimated for the public and private sectors disaggregated by research, comprehensive, baccalaureate, and associate level institutions. The output mix incorporates professional school teaching output, in addition to undergraduate and graduate teaching and research outputs. Scale and scope economies are examined by sector and institutional level, also accounting for regional differences. Ray economies are found throughout the private sector, but confined to lower level public institutions. Research economies are widespread throughout all sector levels. Economies of scope prevail among private institutions across levels, but only among comprehensive and baccalaureate public colleges.     

Politico-economic models and cycles

Studies are surveyed analyzing the mutual interaction of economy and polity in an empirically testable way. A wide variety of assumptions are made concerning the behaviour of economic and political decision-makers–in particular voters and government, as well as the economic and political sectors. Representative models are discussed considering steady state equilibria and political business cycles, and empirical results are presented for the U.S., the U.K. and Germany. Finally, the potential and prospects of politico–economic modelling are discussed.     

The Internet and other networks: utilization rates and their implications

Costs of communications networks are determined largely by the maximal capacities of those networks. On the other hand, the traffic those networks carry depends on how heavily those networks are used. Hence, utilization rates and utilization patterns determine the costs of providing services and, therefore, are crucial in understanding the economics of communications networks. A comparison of utilization rates and costs of various networks helps disprove many popular myths about the Internet. Although packet networks are often extolled for the efficiency of their transport, it often costs more to send data over internal corporate networks than using modems on the switched voice network. Packet networks are growing explosively not because they utilize underlying transport capacity more efficiently but because they provide much greater flexibility in offering new services. Study of utilization patterns shows there are large opportunities for increasing the efficiency of data transport and making the Internet less expensive and more useful. On the other hand, many popular techniques, such as some Quality of Service measures and ATM, are likely to be of limited usefulness.     

Entrepreneurship and Independent Professionals: Social and Economic Logics

This study discusses stereotypes of entrepreneurship by looking at the overlapping areas of entrepreneurship, self-employment and professions. Professions are part of the category of self-employment and the study presents empirical findings drawn from a unique empirical dataset from Finland: a survey (N?=?733) including freelance journalists, translators, interpreters and artists at the blurred boundaries between waged work and entrepreneurship. Findings reveal that the professions are clearly different and the manifestations of entrepreneurship vary, reflecting the work and the labor market situation within the profession. Life and work situations of liberal professions cannot be interpreted in simple black-and-white schemes of winners and losers. Instead, many different socioeconomic situations can be found ‘in between,’ which are driven by different social logics. For entrepreneurship research, the study opens up new avenues by taking us beyond the push-pull dichotomy, which over-simplifies the decision to enter self-employment. The term entrepreneurship is often used in an undifferentiated way, and it easily generates myths and stereotypes which are challenged by the study. A narrower and more realistic view shows that there are diverse agents under the flag of entrepreneurship, who are usually not regarded as core entrepreneurs although they exist in everyday life.     

Strong and weak ties in employment and crime

This paper analyzes the interplay between social structure and information exchange in two competing activities, crime and labor. We consider a dynamic model in which individuals belong to mutually exclusive two-person groups, referred to as dyads. There are multiple equilibria. If jobs are badly paid and/or crime is profitable, unemployment benefits have to be low enough to prevent workers for staying too long in the unemployment status because they are vulnerable to crime activities. If, instead, jobs are well paid and/or crime is not profitable, unemployment benefits have to be high enough to induce workers to stay unemployed rather to commit crime because they are less vulnerable to crime activities. Also, in segregated neighborhoods characterized by high interactions between peers, a policy only based on punishment and arrest will not be efficient in reducing crime. It has to be accompanied by other types of policies that take into account social interactions.     

Diversity and innovation

Although the effect of culture on national innovation levels is well-established, previous literature assumes cultural homogeneity within a nation. In this article we analyse two aspects of diversity – ethnic and values – and their impact on national innovation output. We show that ethnic diversity or fractionalization and values diversity are distinct and while the former has a negative effect on innovation, the latter contributes positively. However, countries are bound to have both types of diversity. We find that countries that are ethnically homogenous but diverse in values orientation are the best innovators.     

The Impact of Competition and Trade Unions on Workplace Reform and Organisational and Technological Change

This article addresses two research questions, firstly to test the hypothesis that organisational and technological changes are more likely to occur in the traded goods sector, in the private sector relative to the public sector and in more competitive product markets. Secondly, to examine whether trade unions have a positive or negative effect on the implementation of different types of workplace reforms, and organisational and technological changes. The analysis supports the hypothesis that workplaces in the traded goods sector are more likely to implement organisational and technological changes. It also indicates that workplaces in the private sector are more likely to implement certain types of reforms, whereas workplaces in the public sector are more likely to implement others. However, this study does not provide conclusive evidence that competitive pressure in product markets increases the probability that a firm will implement each workplace reform mentioned in this study. The evidence on unions provides tentative support to the view that more unionised workplaces are less likely to implement the reforms in question.     

Understanding and forecasting aggregate and disaggregate price dynamics

There are doubts regarding the empirical benefits of forecast aggregation. Theoretical research clearly supports forecast aggregation but conflicting results exist in the empirical literature. We search the literature for empirical regularities. One important issue often cited is estimation error and papers which are unsupportive of forecast aggregation often have short spans of data. A second empirical regularity is that researchers frequently use a relatively small number of disaggregates. Our work finds that the greatest benefits to aggregation are realised when a large number of disaggregates are used. This is a natural consequence of the theoretical results. A second critical issue in forecast aggregation is model selection. We suggest a simple guide to model choice based on the empirical properties of the data. In this regard, the extent of comovements between the constituent series determines model choice.     

The Erosion and Sustainability of Norms and Morale

I examine why the performance of an organization is often subject to gradual erosion. I assume that players are motivated partly by psychological factors, norms and morale, and that they are willing to exert extra efforts if others do so. I show that repeated random shocks induce the erosion of the extra efforts supported by norms and morale, but they do not completely decay; in the long run a certain range of efforts are sustainable. Hence different organizations typically enjoy diverse norms and morale, which persist for a long time, in the vicinity of the equilibrium determined by material incentives.     

Sibling gender and wage differences

Family influences on economic performance are investigated. In particular, sibship sex composition is related to hourly wages using data from the National Longitudinal Survey of Youth 1979. The wages of men are increasing in the proportion of siblings who are brothers, but the wages of women are insensitive to sibling gender. Nonwage outcomes are generally unaffected. Contrasts by age structure and demographic group are also presented. The analysis addresses econometric challenges like the endogeneity of fertility and selection into the workforce. In addition, mechanisms such as labour market interactions, human capital investment and role model effects are documented. A questionnaire on job search indicates a same-gender bias in the use of brothers and sisters in obtaining employment. Developmental and psychological assessments suggest that brothers may be associated with worse childhood home environments and more traditional family attitudes among women. The findings are policy relevant and contribute to an understanding of gender differences and earnings inequality.     

Addiction and interaction between alcohol and tobacco consumption

This paper adopts a multi-commodity habit formation model to study whether unhealthy behaviors are related, i.e. whether there are contemporaneous and inter-temporal complementarities between alcohol and tobacco consumptions in Italy. To this aim time series data of per-capita expenditures and prices during the period 1960 to 2002 are used. Own price elasticities are negative and tobacco appears to be more responsive than alcohol demand, although both responses are less than unity. Cross price elasticities are also negative and asymmetric thus suggesting complementarity. A “double dividend” could then be exploited, because public policy needs to tackle the consumption of only one good to control the demand of both. These results show that the optimal strategy for maximizing public revenues would be to raise alcohol taxation more than tobacco taxation. Finally, past consumption of one addictive good does not significantly reinforce current consumption of the other. We thank participants to the Annual Conference of the European Society for Population Economics, Verona June 2006; the 61st European Meeting of the Econometric Society, Vienna August 2006, and participants of the conference “Individual and Collective Choices in Health Protection”, Genoa November 2005 for helpful comments. We would also like to thank, without implicating, Pier Luigi Rizzi and two anonymous referees for helpful comments. Financial support from the University of Siena, PAR grant (Atheneum Research Grant), is gratefully acknowledged.     

中国和俄罗斯农产品贸易:动态及展望

中俄同为金砖四国成员国又是近邻,经贸联系日益密切,互为重要的农产品贸易伙伴。两国出口的主要农产品均为本国具有比较优势的农产品,贸易互补性较强,其农产品的贸易模式主要是产业间贸易,产业内贸易水平不高。     

Delinquency and gender

The determinants of juvenile delinquency for males and females using the Delinquency in a Birth Cohort II Study are investigated. Ordered probit models for juvenile arrest are estimated separately for males and females. The results indicate that juvenile arrests for both males and females are more likely for non-whites and for those who leave education early. Males and females behave differently, in that males are more likely to be repeat offenders.     

Asymmetry and Duration Dependence in Australian GDP and Unemployment

The periodic structure of business cycles suggests that significant asymmetries are present over different phases of the cycle. This paper uses markov regime-switching models with fixed and duration dependent trasition probabilities to directly model expansions, contractions and durations in Australian GDP growth and unemployment growth. Evidence is found of significant asymmetry in growth rates across expansions and contractions for both series. GDP contractions exhibit duration dependence implying that as output recessions age the likelihood of switching into an expansion phase increases. Unemployment growth does not exhibit duration dependence in either phase. Evidence is also presented that non-linearities in unemployment growth are well explained by the asymmetries in the GDP growth cycle. The analysis suggests that recessions are periods of rapid and intense job destruction, that Australian unemployment tends to ratchet up in recessionary periods and, in contrast to US and UK studies, that shocks to Australian unemployment growth are more persistent in recessions than expansions.     

Crime,inequality and unemployment in England and Wales

A model of crime is developed based on principles from the existing literature with some original insight. The implications of the model are that income inequality and unemployment are important explanatory variables for crimes motivated by economic gain, but do not offer much explanatory power for other types of crime. Panel data of UK regions over the years from 2002 to 2007 are then used to test these predictions. The empirical results strongly support the hypothesis that crime is an economic phenomenon.     

Agriculture and economic development in sub-Saharan Africa and Asia

This paper is a comparative study of the role of agriculturein economic development in sub-Saharan Africa and Asia. Popularnotions of economic duality and agricultural squeeze in sub-SaharanAfrica are re-examined, and new explanations in terms of agrarianstructures and resource availabilities are put forward to accountfor the apparent economic duality in that continent. Comparisonwith surplus labour economies of Asia highlights the constraintsposed by the prevailing agrarian structures for capital accumulationand industrialisation in post-colonial sub-Saharan Africa. Policyconclusions from this new perspective are contrasted with theconventional policies focusing on price reform and market liberalisation.     

Access to credit and informality among micro and small enterprises in Ethiopia

This paper examines the determinants of Micro and Small and Enterprises (MSEs) access to credit in Ethiopia using detailed firm‐level data collected in 2003. Its basic purpose is to identify the various attributes of a firm that determine its access to credit with an emphasis on the role of firm formality. We find that informal firms are more credit constrained compared to formal firms. A firm’s location, membership of a business association and maintaining an accounting record are found to be important determinants of access to credit. Further, we find firms whose owners have vocational training are more credit constrained than those who are not, as are firms that are exclusively male owned. There is no systematic relation between access to credit and a firm’s age, size and the sector in which it operates. The paper concludes with possible policy interventions designed to improve access to credit for MSEs in Ethiopia.     

Niches and economic competition: implications for economic efficiency,growth and diversity

This article examines the relationship between market niches and economic competition and explores the consequences of niches for economic efficiency, growth and diversity of commodities. Concepts of a niche in everyday use, ecology, economics and business management are compared. Factors giving rise to market niches, some of which are institutional, are identified, and their links with barriers to entry and mobility are discussed. Common negative views about their consequences for competition and economic efficiency are outlined. However, the availability of niches can potentially have a very positive impact on economic growth and development as well as on the diversity of commodities. New measures of global diversity of commodities are introduced. Economic globalisation involves institutional change that reduces the availability of niches and threatens long-term economic growth and diversity of commodities. Niches also provide frictions in economic systems and may have stabilising properties.