五年梦寻丰子恺--?丰子恺全集?责编手记

近几年来，社会各界兴起了一股“丰子恺热”。海豚出版社社长俞晓群成为这股热潮的最初发动者。五年来，海豚出版社出版了丰子恺著作达一百多种，将丰子恺生前几乎所有的单行本集子予以再版。同时，海豚出版社还与杭州师范大学弘一大师??丰子恺研究中心合作整理?丰子恺全集?，并将于2015年出版问世。     

Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with α-fetoprotein concentrations of at least 400 ng/ml

Abstract

Objective: This study aimed to compare the cost-effectiveness of ramucirumab versus placebo for patients with hepatocellular carcinoma who progressed on sorafenib with α-fetoprotein concentrations (AFP) of at least 400?ng/ml in the United States.

Methods: A Markov model was constructed to assess the cost-effectiveness of ramucirumab. Health outcomes were measured as quality-adjusted life years (QALYs). With TreeAge software, the disease process was modeled as three health states: progression-free survival (PFS), progressive disease (PD), and death. Costs were extracted from the REACH-2 trial, and utility was derived from published literature. Incremental cost-effectiveness ratios (ICERs) were calculated to compare ramucirumab with placebo. Probabilistic sensitivity analyses were developed to examine the robustness of the results.

Results: In the base case analysis, ramucirumab therapy had a cost of $55,508.41 and generated 0.54 QALYs, while placebo therapy had a cost of $761.09 and generated 0.47 QALYs, leading to an additional $54,747.32 in costs and 0.07 QALYs. The ICER was $782,104.57 per QALY, which was much higher than the willingness-to-pay threshold of $100,000 per QALY. According to sensitivity analyses, the utility of PD in the two groups was the dominant parameter influencing the ICER.

Conclusion: Although ramucirumab was associated with prolonged survival for patients with advanced hepatocellular carcinoma who progressed on sorafenib treatment with an AFP of at least 400?ng/ml, it is not a cost-effective treatment from a United States payer perspective.     

加强新时代高校宿舍舍长队伍建设,助力“00后”大学生成长成才

加强新时代高校宿舍舍长队伍建设,更有利于积极发挥高校宿舍育人阵地的作用,高校宿舍舍长在教育管理工作中的重要性不可忽视。论文提出从提高新时代宿舍舍长工作的站位、加强宿舍舍长的角色认同与培养、加强宿舍舍长管理机制的制度建设三个方面,加强高校宿舍舍长队伍的建设,助力新时代“00后”大学生的成长成才。     

高职高专院校大学生职前培训面临的问题及对策

大学生就业难已经不是一个新话题,高职高专院校的大学生在庞大的就业大军面前,竞争优势并不明显。要想提高就业能力只有加强高职高专学生的"职业"技能,与企业进行无缝对接,才能提高其与本科院校的竞争力,这就需要高职高专院校加强职前培训。本文分析当前高职高专院校职前培训存在的问题,并提出了相关解决路径,希望文中所提出的建议能对高职高专院校的职前培训环节起到一定的参考作用。     

Soros’ ’War’ on the Yuan Unlikely to Win

Billionaire investor George Soros declared a"war"against China at this year’s World Economic Forum held in Davos,Switzerland,from January 20-23,betting that Asian currencies would fall against the dollar.Due to his influence,fluctuations in the international financial market have intensified,and Asian currencies are facing increased pressure from speculative attacks.However,there is no doubt that Soros"challenge against the yuan and Hong Kong dollar is unlikely to succeed.     

我国西部欠发达地区服务业集群发展政策研究——以甘肃为例

采用定量研究的方法,通过制度效应与甘肃经济服务化水平二者关系的实证分析,了解原有的计划经济体制的确是阻碍服务业发展的重要因素,而现有的社会主义市场经济体制更加适宜服务业发展。在此基础上,科学定位了政府在发展服务业中的角色,提出了甘肃服务业集群发展的政策建议。     

华蓥山自然保护区大型真菌资源多样性调查与研究

为了解和合理开发华蓥山自然保护区的大型真菌资源,对保护区内的大型真菌进行了连续一个月的调查与研究。结果表明:该保护区内有大型真菌57种,隶属5纲7目24科43属。其中担子菌亚门层菌纲种类最多,有50种,分属18科37属,占鉴定样本总数的91.2%。保护区内植被类型众多,主要有阔叶林、针叶林、混交林以及灌木草甸,其中灌木草甸中大型真菌最多,有32种,占鉴定样本总数的56.1%。保护区内具有经济价值的大型真菌种类众多,在食用和药用等方面具有较大的开发潜力。     

我国新型农村金融机构存在的问题及对策分析

我国的新型农村金融机构自成立和运行以来,取得了一定的成绩,但也存在着若干问题亟待解决。本文分析了新型农村金融机构运行中存在的问题,并提出改进现状的相关建议,以更好地发挥新型农村金融机构在新农村建设中的作用。