政府背景风险投资对创新的甄选与培育效果——不同区域环境视角的检验

以创业板企业数据为样本，使用Logit模型及工具变量法，研究不同区域环境下政府背景风险投资对企业创新的事前甄选与事后培育作用，并对其机制进行探讨。结果表明：①经济区域对政府背景风险投资行为影响有限，与非核心发达地区相比，金融发达地区的政府背景风险投资对企业技术创新没有表现出差异性甄选行为，但却有更好的事后培育作用，而且这种培育作用会随着地区投资环境优化而增强；②行政区域对政府背景风险投资行为影响显著，与异省投资相比，本省政府背景风险投资对技术创新的事前甄选具有显著优势，但对被投企业后续创新投入产生了一定的负面作用，这种作用会因政府背景风险投资占有董事会席位而加大。     

水处理生物学的多媒体教学

进行“水处理生物学”教学时,恰当地运用多媒体技术、合理地设计课件内容,才能制作出高质量的课件;运用多媒体教学,精心组织安排教学过程,才能取得良好的教学效果。     

基于会计信息化的销售单据核销处理

ERP-U8是用友公司近年推出的针对中小型企业的最新企业管理软件,本文根据会计电算化实务操作的体会,对运用用友软件销售单据核销处理的几种情况进行了阐述,供实务工作者参考。     

The economic burden of common adverse events associated with metastatic colorectal cancer treatment in the United States

Aims: Adverse events (AEs) associated with treatments for metastatic colorectal cancer (mCRC) may compromise the course of treatment, impact quality-of-life, and increase healthcare resource utilization. This study assessed the direct healthcare costs of common AEs among mCRC patients in the US.

Methods: Adult mCRC patients treated with chemotherapy or targeted therapies were identified from administrative claims databases (2009–2014). Up to the first three mCRC treatment episodes per patient were considered and categorized as with or without the AE system/organ category during the episode. Total healthcare costs (2014 USD) were measured by treatment episode and reported on a monthly basis. Treatment episodes with the AE category were matched by treatment type and line of treatment to those without the AE category. Adjusted total cost differences were estimated by comparing costs during treatment episodes with vs without the AE category using multivariate regression models; p-values were estimated with bootstrap.

Results: A total of 4158 patients with ≥1 mCRC treatment episode were included (mean age?=?59 years; 58% male; 60% with liver and 14% with lung metastases; 2,261 [54%] with a second and 1,115 [27%] with a third episode). On average, two treatment episodes were observed per patient with an average length of 166 days per episode. Adjusted monthly total cost difference by AE category included hematologic ($1,480), respiratory ($1,253), endocrine/metabolic ($1,213), central nervous system (CNS; $1,136), and cardiovascular ($1,036; all p?Limitations: Claims do not include information on the cause of AEs, and potentially less severe AEs may not have been reported by the physician when billing the medical service. This study aimed to assess the association between costs and AEs and not the causation of AEs by treatment.

Conclusions: The most costly AEs among mCRC patients were hematologic, followed by respiratory, endocrine/metabolic, CNS, and cardiovascular.     

网络舆论监督与中国行政腐败的预防治理

当前互联网在舆情反映和舆论监督方面开始实质性地发挥作用,在应对行政腐败的层面,体现出确保反腐独立、克服地方保护和升级民主法治三个特征。网络舆论监督对行政腐败的预防与治理发挥着积极的作用,但网络舆论监督也有它的缺陷,诸如网络信息的准确性无法核实和情绪性言论泛滥等较为突出的问题,都需要政府部门加强应对的主动性,最大化地发挥网络的积极功效。     

劳动合同对于进城务工人员收入影响的有效性分析

本文重点讨论了《劳动合同法》的颁布对于进城务工人员收入的影响,我们用博弈论模型证明了签订劳动合同可以提高务工人员的收入,并且在一定条件下企业也可以通过生产率的上升而获利,实现双赢。从统计上看,签订合同的工人月收入高出347.19元,小时收入高出2.16元,OLS回归结果也发现合同对于收入有显著的正影响。但同时我们注意到有合同的劳动者本身有着更好的素质,Probit和Logit模型都验证了这一点,基于这种可能的内生性偏误,我们使用了处置效应来控制这一问题,并发现签订合同依旧显著提高了收入,估计月收入提高14.0%—14.9%,小时收入提高18.2%—21.5%。     

Matching-adjusted indirect comparison of adalimumab vs etanercept and infliximab for the treatment of psoriatic arthritis

Abstract

Objectives:

No head-to-head trial has compared the efficacy of adalimumab vs etanercept and infliximab for psoriatic arthritis (PsA). This study implements a matching-adjusted indirect comparison technique to address that gap.

Methods:

Patient-level data from a placebo-controlled trial of adalimumab (ADEPT) were re-weighted to match average baseline characteristics from pivotal published trials of etanercept and infliximab. ADEPT patients were re-weighted by odds of enrollment in comparator trials, estimated using logistic regression. Matched-on characteristics included PsA duration, age, gender, severity, active psoriasis, and concomitant treatment. After matching, placebo-adjusted treatment arms were compared at weeks 12 (or 14) and 24. Outcomes included ACR20/50/70, PsARC, HAQ, and modified TSS. PASI50/75/90 were compared for patients with active psoriasis. Cost per responder (CPR) was assessed in the US and Germany using matching-adjusted end-points and drug list prices. Statistical significance was assessed using weighted t-tests.

Results:

After matching, adalimumab-treated patients had greater placebo-adjusted rates of ACR70 and PASI50/75/90 at week 24 compared with etanercept (all p?<?0.05). Adalimumab patients had a higher placebo-adjusted rate of ACR70 than infliximab at week 14 (p?=?0.034). Adalimumab treatment had lower CPR for ACR70 and PASI50/75/90 compared with etanercept at week 24, in both the US and Germany (all p?<?0.02). Adalimumab had lower CPR than infliximab for all outcomes at week 24 (all p?<?0.05).

Conclusion:

Adalimumab is associated with higher ACR70 and PASI50/75/90 response rates than etanercept at week 24 and a higher ACR70 response rate than infliximab at week 14. Adalimumab has significant advantages over etanercept and infliximab in CPR across multiple end-points.

Key limitations:

The matching-adjusted indirect comparison method cannot account for unobserved differences in patient characteristics across trials, and only a head-to-head randomized clinical trial can fully avoid the limitations of indirect comparisons. CPR findings are limited to the US and German markets, and may not be generalizable to other markets with different relative pricing.     

Minimax regret treatment choice with covariates or with limited validity of experiments

This paper continues the investigation of minimax regret treatment choice initiated by Manski (2004). Consider a decision maker who must assign treatment to future subjects after observing outcomes experienced in a sample. A certain scoring rule is known to achieve minimax regret in simple versions of this decision problem. I investigate its sensitivity to perturbations of the decision environment in realistic directions. They are as follows. (i) Treatment outcomes may be influenced by a covariate whose effect on outcome distributions is bounded (in one of numerous probability metrics). This is interesting because introduction of a covariate with unrestricted effects leads to a pathological result. (ii) The experiment may have limited validity because of selective noncompliance or because the sampling universe is a potentially selective subset of the treatment population. Thus, even large samples may generate misleading signals. These problems are formalized via a “bounds” approach that turns the problem into one of partial identification.In both scenarios, small but positive perturbations leave the minimax regret decision rule unchanged. Thus, minimax regret analysis is not knife-edge-dependent on ignoring certain aspects of realistic decision problems. Indeed, it recommends to entirely disregard covariates whose effect is believed to be positive but small, as well as small enough amounts of missing data or selective attrition. All findings are finite sample results derived by game theoretic analysis.     

浅谈高大平房仓粮食发热的预防与处理

粮食发热现象是保管过程中普遍存在的问题。为减少发热现象带来的危害,应认真对待以下3个问题：①找出粮食发热现象的9个方面的原因,为预防及发热后的处理提供依据。②在保管过程中,预防在先,采用9种有效措施防止发热现象的发生。③粮食已出现发热现象,就必须根据产生发热的不同原因,分别进行通风、降温、降水、杀虫、翻仓等手段进行及时处理,减少粮食损失。