The economic burden of depression among adults with rheumatoid arthritis in the United States

Aims: Depression is the most frequent comorbidity reported among patients with rheumatoid arthritis (RA). Comorbid depression negatively impacts RA patients’ health-related quality-of-life, physical function, mental function, mortality, and experience of pain and symptom severity. The objective of this study was to assess healthcare utilization, expenditures, and work productivity among patients with RA with or without depression.

Materials and methods: Data from adult patients who had at least two visits each related to RA and depression over a 1-year period were extracted from the Truven Health MarketScan research databases. Outcomes comprised healthcare resource utilization, work productivity loss, and direct healthcare costs comparing patients with RA with depression (n?=?3,478) vs patients with RA without depression (n?=?43,222).

Results: Patients with RA and depression had a significantly greater relative risk of hospitalization and number of all-cause and RA-related hospitalizations, utilization of emergency services, days spent in the hospital, physician visits, and RA-related surgeries compared with RA patients without depression. Patients with RA and depression had a higher risk of and experienced more events and days of short-term disability compared with patients without depression. The incremental adjusted annual all-cause and RA-related direct costs were $8,488 (95% CI = $6,793–$10,223) and $578 (95% CI = –$98–$1,243), respectively, when comparing patients with RA and depression vs RA only.

Limitations: The current analysis is subject to the known limitations of retrospective studies based on administrative claims data.

Conclusions: This study suggested increased healthcare utilization, work productivity loss, and economic burden among RA patients due to comorbid depression. These findings emphasize the importance of managing depression and including depression as a factor when devising treatment algorithms for patients with RA.     

高质量发展导向下国家级新区空间优化——基于双效评价与四分图分析

国家级新区是国家区域空间生产策略的体现,新时期高质量发展对其空间优化提出新要求.基于产城融合、区域协同与双效提升的高质量发展目标体系,构建国家级新区空间优化效果—效率双评价四分图模型,比较分析浦东、滨海等6个国家级新区2011～2017年空间优化水平.研究发现:(1)6个国家级新区空间优化水平整体呈现马太效应,低效果—低效率的新区间差距呈扩大趋势.(2)国家级新区空间优化水平存在南高北低的区域差异,南部4个新区中,2010年前成立的新区空间优化水平更高.(3)国家级新区空间优化效果与效率总体均值呈现类雁形与"乀"形变化.从以动态评价赋能精准施策、以绿色创新推动产城融合、以开放协调带动新区合作、以双效提升引导差异化发展等方面提出国家级新区空间优化的建议.     

基于社会服务的示范性高职院校师资队伍建设——以广东农工商职业技术学院为例

服务是高职院校的第一宗旨,而社会服务能力的高低关键在于示范院校师资队伍建设。该文从广东农工商职业技术学院社会服务能力的实际情况出发,分析了该院师资队伍建设存在的问题,认为,首先应通过体制创新,提高教师社会服务意识;其次通过不同途径打造"双师型"教师团队,从而提升教师社会服务能力。     

加油站用户忠诚度培育策略探讨

从分析加油站培育用户忠诚度的功能入手,着重探讨了加油站用户忠诚度的培育策略,包括:用户满意的经营理念;新老并重的用户观念;优先对待核心用户;亲和友善、真诚守信的用户关系;让利于人的用户策略;打造有"魅力"的产品;优质完善的服务体系;卓有成效的促销手段;鲜明感人的企业形象;优先对用户忠诚的经营原则.同时指出,加油站培育用户忠诚度必须有领导的高度重视和亲自参与;要从实际出发,对症下药,有的放矢;应实实在在地行动,点点滴滴地积累,不流于形式或浅尝辄止,并且应与当前石油系统开展的"CS工程"、"TQM"、"HSE"、实施名牌战略、创质量管理奖、加油站"达标创新"等活动有机地结合起来.     

C++对象布局分析

分析了目前最为流行的面向对象的开发工具C 的对象布局，并进一步分析了其形成原因。     

关于开展航海职业教育扶贫工作的探讨

建设新农村的核心环节是提高农民收入。对贫困地区进行扶贫是党和政府解决贫困地区农民问题的重要手段之一,其中心工作是提高农民收入。通过开展航海职业教育扶贫工作可以有效地帮助转移农村富余劳动力,提高农民综合素质,增加农民收入,增强农民自身的造血功能,彻底改变贫穷的面貌;同时也有利于促进航运业和航海职业教育的发展。开展航海职业教育扶贫工作是一个多方合作共赢的过程。     

中国银行业跨国并购的同心圆战略

当前的全球银行跨国并购浪潮，是在第五次全球企业并购浪潮下产生的，中国银行业要抓住这一历史机遇，通过实施“同心圆”战略，从企业竞争上升到产业竞争的高度去整合全球金融资源，建立起自己的产业价值链优势，在国际金融博弈中获得先发优势。     

关税、配额与补贴：效果分析与政策取向

关税、配额与补贴是一个国家用来保护国内市场、帮助国内厂商抵御国外对手竞争的常用措施.由于保护机制不同,关税、配额与补贴对不同利益主体的利益再分配会产生不同的影响.因此,一个国家可以根据其要保护的利益主体不同采取相应的保护措施.     

Innovative productivity and returns to scale in the pharmaceutical industry

This study shows that firms in the pharmaceutical industry experience decreasing returns to scale in R & D as the level of R & D expenditures rises. The paper presents the results of our study of the innovative output of 16 pharmaceutical firms over a 19 year period. Given the strong correlation between R & D budgets and firm size, our study suggests the wave of mergers in the industry may yield less innovative productivity than managers expect.     

金融资本国际化绩效与条件分析

金融资本国际化一方面促进利率水平提高,从而促进储蓄增加;另一方面影响投资规模和投资效率,进而影响经济绩效。一国实施金融资本国际化的条件可以分为国内条件,即初始条件和对外条件,即可实施条件两个方面。