Burden of illness for super-refractory status epilepticus patients

Objective: To provide an estimate of the annual number of super-refractory status epilepticus (SRSE) cases in the US and to evaluate utilization of hospital resources by these patients.

Methods: The Premier Hospital Database was utilized to estimate the number of SRSE cases based on hospital discharges during 2012. Discharges were classified as SRSE cases based on an algorithm using seizure-related International Classification of Diseases-9 (ICD-9) codes, Intensive Care Unit (ICU) length of stay (LOS), and treatment protocols (e.g. benzodiazepines, anti-epileptic drugs (AEDs), and ventilator use). Secondary analyses were conducted using more restrictive algorithms for SRSE.

Results: A total of 6,325 hospital discharges were classified as SRSE cases from a total of 5,300,000 hospital discharges. Applying a weighting based on hospital characteristics and 2012?US demographics, this projected to an estimated 41,156 cases of SRSE in the US during 2012, an estimated incidence rate of ～13/100,000 annually for SRSE in the US. Secondary analyses using stricter SRSE algorithms resulted in estimated incidence rates of ～11/100,000 and 8/100,000 annually. The mean LOS for SRSE hospitalizations was 16.5 days (median =11; interquartile range [IQR]?=?6–20), and the mean ICU LOS was 9.3 days (median =6; IQR =3–12). The mean cost of an SRSE hospitalization was $51,247 (median = $33,294; 95% CI = $49,634–$52,861).

Limitations: The analysis uses ICD-9 diagnostic codes and claims information, and there are inherent limitations in any methodology based on treatment protocol, which created challenges in distinguishing with complete accuracy between SRSE, RSE, and SE on the basis of care patterns in the database.

Conclusion: SRSE is associated with high mortality and morbidity, which place a high burden on healthcare resources. Projections based upon the findings of this study suggest an estimated 25,821–41,959 cases of SRSE may occur in the US each year, but more in-depth studies are required.     

中国财政刺激将经济拉出低谷？

【英国《金融时报》4月17日】即便中国第一季度国内生产总值（GDP）数据是近20年来最糟糕的,但16日发布的一批新数据显示,政府的大笔支出,使中国经济脱离了最严重的低迷阶段。     

Does it really pay to do better? Exploring the financial effects of changes in CSR ratings

Previous literature on the link between corporate social responsibility (CSR) and financial performance has focused mainly on the financial implications of a firm’s level of CSR without considering the potential effects on financial performance of variations in CSR rating. We try to fill this gap by studying whether variations in a firm’s CSR rating affect systematic risk, firm value, and portfolio performance. First, our results show that an increase in firms’ CSR efforts, as reflected by an increase in their CSR ratings, significantly reduces systematic risk. Second, a positive variation in CSR ratings significantly improves firm value. Finally, from a portfolio perspective, a strategy that consists of buying stocks that have experienced a CSR ratings increase and selling stocks that have experienced a CSR ratings decrease (or remain stable) leads to lower financial performance. Taken together, our findings provide new evidence and financial implications for firms and portfolio managers.     

A sequential model for cracking down on street markets for illicit drugs

This paper develops a sequential decision-making model for assisting law enforcement officials in allocating resources during a crackdown operation on illicit drug markets. The sequential crackdown model (SCM) considers a probabilistic framework, where the probability of incarceration of a dealer and the probability of dealing are modeled as a function of the size of a drug market, crackdown enforcement level, drug dealer's financial hardship, and other market characteristics.The model was developed and tested in consultation with enforcement officials from Philadelphia, PA and Camden, NJ. We present a detailed, step-by-step implementation scheme for updating parameters on each day of the crackdown. Parameter estimation along with examples of model usage is provided. Through these examples, we illustrate how the SCM could be helpful in understanding the response of illicit drug markets to various enforcement strategies. We further show conditions under which an alternating crackdown policy (referred to as a crackdown-backoff) or a consistent use of maximum possible enforcement would be optimal strategies for managing a drug crackdown operation. Within the context of the model and parameter estimates, we show that a much quicker and less costly collapse could be implemented if the available enforcement resources are increased. Finally, the model provides possible conditions under which a crackdown operation would be unsuccessful in eliminating a drug market.     

Why households buy bottled water: a survey of household perceptions in the Philippines

This study investigates the determinants of household buying decisions to purchase bottled water or purified water from refilling stations among households in Metro Cebu, Philippines. A survey of 360 households was conducted to obtain data on household sources of drinking water, household bottled water buying behaviour and perceptions of water quality. A binary probit model was used to examine the effects of socio‐economic and perception‐based variables on the likelihood that a household regularly bought bottled or purified water. Results show that households that perceived their primary source of water, whether from the tap or from other sources, to be unsafe were more likely to buy bottled or purified water. Education of household heads, the presence of children ages 0–5 years, household size and price were also found to have significant effects. Income, however, was not found to have influenced the decision to buy. Having piped access to the local water district and knowledge of government assurances about water safety were also not found to have a significant impact.     

Braverman and the Structure of the U.S. Working Class: Beyond the Degradation of Labor

The fortieth anniversary of Harry Braverman’s Labor and Monopoly Capital is the occasion here for a reassessment of his work as a whole. Braverman’s analysis of the degradation of work is shown to have been only a part of a much larger argument he was developing on the structure of the U.S. working class. Building on his pioneering empirical research into occupational composition, a new empirical assessment of the structural evolution of the U.S. working class over the last four decades is provided, throwing light on current problems of unemployment, underemployment, and socially wasted labor—and the rights of labor.     

The “hidden hand” behind the resilience of the stateless economy of Somalia

This paper provides a framework of analysis of economic markets in stateless Somalia. It argues that the informal market that sustained private sector activities under the repressive policies of Siad Barré's government has provided a functioning system to the economy. In small communities that achieved internal law and order, their economy boomed in an unprecedented free-market environment, and the no-government situation has proven to be far better than the repressive government institutions and policies of Barré's era. However, the economic expansion is chaotic and there is a strong new demand for an accountable and effective government that could provide essential public goods for sustainable economic development.     

The status quo of omani female entrepreneurs: a story of multidimensional success factors

Quality & Quantity - While the Omani government’s endeavours over two decades to support entrepreneurship, particularly among women, have been significant, research has not substantiated...