前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果

目的探讨前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果。方法选取2018年2月至2020年2月在辽宁省精神卫生中心进行药物治疗的94例糖尿病肾病患者作为研究对象,随机分为对照组与观察组,每组47例。对照组采用厄贝沙坦片进行治疗,观察组采用前列地尔联合厄贝沙坦片进行治疗。比较两组治疗有效率、药物不良反应发生率、血糖、血肌酐、尿素氮、24 h尿微量白蛋白、24 h尿蛋白、糖尿病肾病症状消失时间、肾功能指标复常时间、住院时间。结果观察组治疗有效率为91.5%,高于对照组的72.3%,差异有统计学意义(P<0.05);观察组患者2例(4.2%)发生药物不良反应,对照组9例(19.3%),组间比较差异有统计学意义(P<0.05);治疗后,两组空腹血糖、餐后2h血糖、血肌酐、尿素氮、24 h尿微量白蛋白、24 h尿蛋白水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组糖尿病肾病症状消失时间、肾功能指标检查结果恢复正常时间、住院时间明显短于对照组,差异有统计学意义(P<0.05)。结论前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果显著,可短时间内使患者肾功能和血糖水平得到改善,降低药物不良反应发生率,缩短患者住院时间。

Alprostadil Combined with Irbesartan Tablets in the Treatment of Patients with Diabetic Nephropathy

Objective To explore the clinical effect of alprostadil combined with irbesartan tablets in the treatment of patients with diabetic nephropathy. Methods A total of 94 patients with diabetic nephropathy admitted to Liaoning Mental Health Center were selected as the research objects and were randomly divided into a control group and an observation group, with 47 cases in each group. The control group was treated with irbesartan tablets;and the observation group was treated with alprostadil combined with irbesartan tablets. The effective rate, incidence of adverse drug reactions, blood glucose, serum creatinine, urea nitrogen, 24-hour urinary albumin, 24-hour urinary protein level, disappearance time of diabetic nephropathy symptoms, recovery time of renal function indexes and total hospitalization time of the 2 groups were compared. Results The curative rate of the observation group was 91.5%, higher than 72.3% of the control group, with statistical significance(P<0.05);only 2 cases of adverse drug reactions occurred in the observation group, and 9 cases occurred in the control group, with no significant between-group difference(P<0.05);after treatment, the improvement of blood glucose, serum creatinine, urea nitrogen, 24-hour urinary microalbumin, 24-hour urinary protein levels were lower than those before treatment. And the observation group was lower than the control group, the difference was statistically significant(P<0.05);the diabetic nephropathy symptom disappearance time, renal function index check results returning to normal time, hospital stay in the observation group were significantly shorter than the control group, the difference was statistically significant(P<0.05). Conclusion Alprostadil combined with irbesartan tablets in the treatment of patients with diabetic nephropathy has significant clinical effect, which can shorten the renal function and blood glucose level of patients in a short time, reduce the incidence of adverse drug reactions, shorten the hospitalization time of patients.