虎眼万年青体内抗氧化性的研究

研究虎眼万年青乙醇提取物体内抗氧化性的作用．利用加热回流提取方法提取虎眼万年青总皂苷，分别以高中低（30、15、7．5 mg/kg）三种不同剂量的虎眼万年青乙醇提取物，对小鼠灌胃给药14 d，并以Vc 和水分别作阳性对照和阴性对照．通过测定小鼠血清和肝组织中的超氧化歧化酶（ SOD）和丙二醛（ MDA）值来研究虎眼万年青乙醇提取物体内抗氧化活性．结果表明，与阴性对照（蒸馏水）相比，虎眼万年青乙醇提取物能明显提高小鼠血清和肝组织中SOD的活力，降低MDA的含量（ P＜0．01）；与阳性对照Vc相比，高剂量组血清中SOD的活力显著高于对照组（P＜0．01），且肝组织中MDA的含量显著低于对照组（P＜0．05）．虎眼万年青乙醇提取物具有较强的体内抗氧化活性．

Study on antioxidant activity of Ornithogalum caudatum Ait in vivo

To study the antioxidant effect of ethanol extract of Ornithogalum caudatum Ait in vivo, total saponins of Ornithogalum caudatum Ait was extracted by heat reflux extraction . ethanol extracts of three different doses （30,15,7.5mg/kg） feed mice for 14 days.Vc solu-tion and water were used as positive control and negative control .Detecting numerical chan-ges of the mice serum, liver tissue of malondialdehyde （ MDA） and super oxide dismutase （ SOD） , experimental data was used to analyze and study the tiger yield of ethanol extracts of antioxidant activity in the body .The results showed that compared with negative control （ dis-tilled water ） , ethanol extract of Ornithogalum caudatum Ait could increase serum and liver tissue SOD, decrease MDA content （P 〈0.01）.Compared with the positive control Vc group, a higher concentration of SOD in serum （P 〈0.05） and MDA in liver tissue （P 〈0.05） was detected in high dose group （30 mg/kg） .The results showed that the ethanol ex-tract of Ornithogalum caudatum Ait showed good antioxidant activity .