Evaluation of the long-term cost-effectiveness of liraglutide therapy for patients with type 2 diabetes in France |
| |
Authors: | Ronan Roussel Luc Martinez Habiba Douik Patrick Emiel Matthieu Guery |
| |
Institution: | 1. AP-HP, Bichat Hospital, Department of Diabetology-Endocrinology-Nutrition, Department Hospital University FIRE, Paris, France;2. INSERM, UMRS 1138, Centre de Recherche des Cordeliers, Paris, France;3. University Paris Diderot Sorbonne Paris Cité, UFR de Médecine, Paris, France;4. Department of General Practice, Pierre et Marie Curie University, Paris, France;5. Novo Nordisk Pharmaceutique SAS, Paris, France |
| |
Abstract: | Objectives:The present study aimed to compare the projected long-term clinical and cost implications associated with liraglutide, sitagliptin and glimepiride in patients with type 2 diabetes mellitus failing to achieve glycemic control on metformin monotherapy in France.Methods:Clinical input data for the modeling analysis were taken from two randomized, controlled trials (LIRA-DPP4 and LEAD-2). Long-term (patient lifetime) projections of clinical outcomes and direct costs (2013 Euros; €) were made using a validated computer simulation model of type 2 diabetes. Costs were taken from published France-specific sources. Future costs and clinical benefits were discounted at 3% annually. Sensitivity analyses were performed.Results:Liraglutide was associated with an increase in quality-adjusted life expectancy of 0.25 quality-adjusted life years (QALYs) and an increase in mean direct healthcare costs of €2558 per patient compared with sitagliptin. In the comparison with glimepiride, liraglutide was associated with an increase in quality-adjusted life expectancy of 0.23 QALYs and an increase in direct costs of €4695. Based on these estimates, liraglutide was associated with an incremental cost-effectiveness ratio (ICER) of €10,275 per QALY gained vs sitagliptin and €20,709 per QALY gained vs glimepiride in France.Conclusion:Calculated ICERs for both comparisons fell below the commonly quoted willingness-to-pay threshold of €30,000 per QALY gained. Therefore, liraglutide is likely to be cost-effective vs sitagliptin and glimepiride from a healthcare payer perspective in France. |
| |
Keywords: | Cost Cost-effectiveness Type 2 diabetes mellitus France Incretin therapy Liraglutide |
|
|