美国反垄断领域的福利转移市场——利益集团对反垄断法目标的异化

反垄断法是美国市场经济的基本法。长期以来,人们一直认为反垄断法的制定与实施都以公共利益为目标追求。而事实上,反垄断法自始至终都受到利益集团的利用与滥用,并因而严重地偏离了公益方向,由阻却市场力量的利器异化为谋取集团私利最大化的工具。     

经济全球化进程中城市群发展的制度创新

从我国城市群目前的发展现状来看,影响城市群发展的主要因素是制度障碍:城市群跨界需求与行政区分割的障碍、缺乏城市群一体化发展的协调政策、没有形成有效的空间管理机制。因此,制度创新应是发展我国城市群的关键所在,重点是在法律制度、空间规划和管理制度等方面的创新。     

投资选择权约束、意见分歧与中国股市风险

特定的股票总是被市场上特定的投资者群体持有 ,以反映该投资者群体对投资资产价格的评估意见。投资者意见的分歧会导致股票市场的资产出清价格偏离均值 ,股票价格趋于均衡的波动幅度也会变大。中国股市上投资者投资选择权的约束加大了投资者的意见分歧。扩大投资者的投资选择权来促进投资者意见分歧程度的缩小能有效降低中国股市的风险。     

我国农业生态系统营养循环链的断裂与重建

完整的营养循环是农业生态系统健康、可持续发展的重要保障。我国传统农业属于环境友好型生态农业。农业生态系统的营养循环结构完整，持续健康、繁荣。但是，随着工业化、城市化、市场经济的发展以及农业耕作方式的转变，农业生态系统营养循环的结构遭到严重破坏，导致一系列资源、环境、经济与社会问题。通过秸秆还田以及城市生活废弃物（排泄物、厨房垃圾等）向农业生态系统的返还，重建农业生态系统完整的营养循环，是我国农业生态系统持续健康发展的必由之路。     

Health Damage of Air Pollution: An Estimate of a Dose–Response Relationship for the Netherlands

This paper estimates the dose-response relationship between air pollution and the number of work loss days for the Netherlands. The study is based on illness data (work loss days) for the Dutch labour population and average year concentrations of air pollution in 29 districts. The dose-response relationship has been estimated by means of two different techniques: the ordinary least squares method (OLS) and the one-way fixed-effects method (OWFEM), which we consider to be more adequate. In general health effects are much smaller when OWFEM is applied than if OLS is used. With OWFEM a significant relationship is found between sulphate aerosol (SO₄), ammonia (NH₃) and the number of work loss days (WLDs). Particulates (TSP), O₃ and SO₂ have no significant effect on the number of WLDs. These results differ from those obtained in studies in the United States, which indicate that particulates (TSP) and other small particles, ozone (O₃) and to a lesser extent SO₄ and SO₂ significantly influence the number of WLDs.     

基于时空路径的城市绿地享用公平性 研究——以成都市新、旧城区为例

从时空间行为视角切入，采用居民活动日志搜集成都市新、旧城区的绿地使用者时空路径数据集，辨识不同时间预算人群的潜在可用绿地分布及人群特征，并通过构建绿地时空享用量模型，从时空制约角度对成都市新、旧城区的绿地享用公平性展开分析。研究结果显示：1)成都市新、旧城区的绿地享用格局在辐射范围、享用强度和人群绿地享用时间预算方面具有时空间分异特征；2)日常出行链中固定性活动占比会对人群绿地享用时间预算产生影响；3)随个体时间预算不断被固定性活动所挤占，长距离通勤加班族、担负接送小孩上学的上班族等时间短缺型群体的绿地享用机会被深度制约，日益成为潜在的绿地享用弱势群体，在时间短缺型群体的潜在活动路径范围内增加绿地供给，有利于提高此类人群享用绿地的机会，从而提高片区的整体绿地享用公平性。     

2017年北京社区卫生服务中心处方集中点评结果

目的汇总分析北京市16个区县近100家社区卫生服务中心处方抽样点评的结果,比较各区之间的差异,细化点评结果,促进全市合理用药。方法抽取2017年6月第2周,全门诊不包括草药处方,共计50189张处方,进行精细化集中点评。结果2017年北京16个区县社区卫生服务中心平均处方金额为160.07元,注射剂使用率为5.56%,全部基本药物占比为68.29%,处方的不合理率为8.8%。结论对于北京市社区卫生服务中心门诊处方集中点评最应改进的为统一点评标准,其次还应完善处方管理,强化药剂师自身的业务学习.     

A review and validation of overall survival extrapolation in health technology assessments of cancer immunotherapy by the National Institute for Health and Care Excellence: how did the initial best estimate compare to trial data subsequently made available?

Background: Validation of overall survival (OS) extrapolations of immune-checkpoint inhibitors (ICIs) during the National Institute for Health and Care Excellence (NICE) Single Technology Assessment (STA) process is limited due to data still maturing at the time of submission. Inaccurate extrapolation may lead to inappropriate decision-making. The availability of more mature trial data facilitates a retrospective analysis of the plausibility and validity of initial extrapolations. This study compares these extrapolations to subsequently available longer-term data.

Methods: A systematic search of completed NICE appraisals of ICIs from March 2000 to December 2017 was performed. A targeted search was also undertaken to procure published OS data from the pivotal clinical trials for each identified STA made available post-submission to NICE. Initial Kaplan-Meier curves and associated extrapolations from NICE documentation were extracted to compare the accuracy of OS projections versus the most mature data.

Results: The review identified 11 STAs, of which 10 provided OS data upon submission to NICE. The extrapolations undertaken considered parametric or piecewise survival models. Additional data cut-offs provided a mean of 18 months of OS beyond the end of the original data. Initial extrapolations typically under-estimated OS from the most mature data cut-off by 0.4–2.7%, depending on the choice of assessment method and use of the manufacturer- or ERG-preferred extrapolation.

Conclusion: Long-term extrapolation of OS is required for NICE STAs based on initial immature OS data. The results of this study demonstrate that the initial OS extrapolations employed by manufacturers and ERGs generally predicted OS reasonably well when compared to more mature data (when available), although on average they appeared to underestimate OS. This review and validation shows that, while the choice of OS extrapolation is uncertain, the methods adopted are generally aligned with later-published follow-up data and appear appropriate for informing HTA decisions.     

Definitions and progress of ecosystem health and ecological security

1. Introduction Development of human industrial civilization and predatory exploitation of natural resources have in- duced tremendous changes of ecological environment. In recent years, territorial and global environmental problems have increased, such as greenhouse effect, depletion of ozone, global warming, water scarcity, water pollution, acid rain, decrease of biodiversity, soil erosion desertification etc. These changes seriously intimidate the health and security of ecosystems, and dist…     

基于风景健康的海南省自贸区人居环境 空间研究

海南经过30年的经济特区建设已正式迈入自贸区建设的新时代，所面临的地区发展与生态维育矛盾逐步加剧。为保育海南优良的生态品质，提升海南人居环境空间质量，基于“健康、生态、人居”三元耦合与互动多赢的发展关系，提出与之适宜的风景园林健康理论；结合前人经验，以人居环境空间规划为切入点，解析人居环境空间研究内容。运用ArcGIS 10.2.2空间分析和Fragstats 4.2景观格局分析，解析海南省域三生空间敏感性、资源利用效率可持续性，以及资源服务范围与开发建设空间适宜性，结合人居环境空间发展特征，提出从全岛国土空间、资源统筹和空间营造3个方面进行规划引导，并提出以下观点：1)人类活动对资源环境和空间利用的合理性是有效保障海南人居环境空间的前提基础；2)遵循风景园林健康理论指导的全域国土空间规划、资源统筹规划和空间营造规划是提升海南人居环境空间的根本路径；3)“健康、生态、人居”三元耦合和互动多赢的关系均衡与协调是提升海南人居环境空间的终极目标。