区域知识产权保护发展的空间格局及结构体系研究

以我国各省知识产权保护制度为研究对象，创新性地将探索性空间数据分析方法与社会网络分析方法相结合，基于地理邻近视角，验证了区域知识产权保护的空间相关性、空间集聚特征和空间溢出效应。同时，突破地理近邻效应的局限，解析区域知识产权保护的空间关联特征。结果表明：我国各省知识产权保护具有全局自相关性，相似地区间存在空间集聚效应，不同发展程度地区的空间关联性质不同；网络化后的区域知识产权保护各节点间联系紧密、网络结构稳定，并且可以确定核心行动者和边缘行动者角色；长三角、珠三角、环渤海等较发达地区与其它地区之间存在较多溢出关系。     

导航电子地图中的路网经路等级设计方法

导航过程中的路径规划与引导,不仅关系算法,更取决于所用的路网数据.路网有诸多属性和关系,关系到路径规划速度和引导合理性的最重要特征之一就是经路等级,又称拓扑阶层.本文拟从路径规划的原理出发,引出导航电子地图制作中路网经路等级设计的必要性,继而给出经路等级设计的一般规则以及设计方法,最后通过北京、天津、重庆等多个城市路网经路等级的设计结果,验证了所提出的设计方法的可行性和合理性.     

Complex Network of Aviation E-Services in the Belt and Road Initiative: A Heuristic Study of Small Data based on Block Modeling

ABSTRACT

The aviation e-service system is an important part of support for business communication in regions covered by Belt and Road initiative. In exploring the role of airline companies in this system, we examine the structure of the network, which consists of airlines interconnections based on small data of individual attributes of aviation companies in aviation e-services, and study these interconnections across different groups using block modeling. The heuristic solution of airline companies in development of international communication and cooperation is further discussed. Among our policy implications for global managers, we suggest the enhancement of cross-regional cooperation among airlines.     

Can Direct Payments Facilitate Agricultural Commercialisation: Evidence from a Transition Country

We investigate the impact of direct payments on agricultural commercialisation in Kosovo. Kosovo is one of the poorest countries in Europe but, with European assistance, provides substantial funds to support agriculture, made up of many small and often semi‐subsistence farms. Thus, the effect of this support is a central policy issue. Identifying the effect of direct payments on market participation faces endogeneity issues arising from the possible simultaneous determination of participation in support programmes and market participation. In order to achieve proper identification of the endogenous direct payments, we use a strategy of targeted identification search that employs several different methodological approaches. We find that direct payments for fruit and vegetables, and those for cereals and oilseeds have a positive effect on market participation. However, we cannot identify any definite effect of livestock payments.     

湿热地区精装住宅室内甲醛和TVOC污染调查及分析

对宁波精装修后未入住的76户住宅进行甲醛和TVOC浓度检测.统计发现,甲醛和TVOC平均超标率为52.5％和59.1％,儿童房室内污染最严重,高温高湿气候加速甲醛释放,人造板家具比实木家具的污染超标率高3.4倍.     

Childhood adversity and the propensity for entrepreneurship: A quasi-experimental study of the Great Chinese Famine

Studies on the determinants of entrepreneurship emphasize that challenged adults tend to become entrepreneurs. However, research has not addressed the childhood origins surrounding the propensity for entrepreneurship. This article links childhood adversity to the propensity of individuals to become migrant entrepreneurs later in life. We test hypotheses derived from this theory in the context of whether, and when, children who survived the Great Chinese Famine of 1959–1961 became migrant entrepreneurs. Results strongly indicate that those who survived greater hardship during the Famine are more likely to become entrepreneurs, especially when they were younger during the famine years. We also find that being younger at the time of migration increased the likelihood of becoming entrepreneurs in their new locale. Overall, this study casts light on why, how and when childhood adversity shapes the propensity for entrepreneurship.     

阿莫西林克拉维酸钾片含量测定方法的改进

为解决实际应用中克拉维酸钾峰与后相邻杂质的分离度达不到要求的问题,建立了一种同时测定阿莫西林克拉维酸钾片中阿莫西林和克拉维酸钾含量的新方法,采用反相高效液相色谱法(RP-HPLC),Ultimate AQ-C_(18)色谱柱(4.6mm×250 mm,5μm),以pH值为4.4的0.05 mol/L磷酸二氢钠缓冲液为流动相,柱温为35℃,流速为1.0mL/min,检测波长为220nm。结果表明:阿莫西林和克拉维酸钾两主峰与相邻杂质得到完全基线分离,分离度大于1.5;克拉维酸钾对照品溶液质量浓度为0.050 0~0.500 1mg/mL时与峰面积的线性关系良好(r=0.999 8),平均回收率(n=9)为100.14%,RSD值为0.24%;阿莫西林对照品溶液质量浓度为0.100 0~1.000 1mg/mL时与峰面积的线性关系良好(r=0.999 9),平均回收率(n=9)为100.45%,RSD值为0.17%。与原有的《中华人民共和国药典》方法相比,新的阿莫西林克拉维酸钾片含量测定方法专属性好,准确度高,操作简便快捷,结果可靠,可作为一种质量控制方法。     

户籍制度扭曲及放松对经济的影响:理论与实证

户籍制度是我国劳动力流动的主要障碍.那么,当前我国的户籍扭曲程度几何?户籍制度放松对经济又会有怎样的影响?对这些问题的回答将有助于政府评估户籍制度改革的空间和经济效益.文章在Hansen和Prescott(2002)的两部门劳动力流动模型基础上,将工人分为农业和非农户口,引入户籍扭曲因子,构建两部门两类工人的户籍扭曲模型;然后,使用1984?2013年宏观经济数据度量户籍扭曲程度,并对2013年我国户籍制度逐渐放松过程中经济变量的变化进行模拟;最后,文章建立了包含"农业与非农"和"本地与外地"户籍差异的省份异质性户籍扭曲模型.研究表明:(1)经济和户籍制度改革的不同步导致了1984?2013年我国户籍扭曲程度呈现倒"U"形变化,且相较于韩国尚有较大的改善空间;(2)以韩国为参照,若2013年我国户籍制度完全放开,经济达到均衡时,农业部门和非农部门的就业人数将分别下降58.83%和上升26.92%,工资率将分别上升19.44%和下降6.77%,社会增加值将增长15.33%,这说明社会经济效率将得到提升,贫富差距将缩小.文章丰富和完善了户籍扭曲的理论模型,从减少劳动力流动摩擦的视角为政府制定相关政策提供了参考.     

Cost comparison of continued anticoagulation with rivaroxaban versus placebo based on the 1-year EINSTEIN-Extension trial efficacy and safety results

Aims: The EINSTEIN-Extension trial (EINSTEIN-EXT) found that continued treatment with rivaroxaban for an additional 6 or 12 months (vs placebo) after 6–12 months of initial anticoagulation significantly reduced the risk of recurrent venous thromboembolism (VTE) with a small non-significant increased risk of major bleeding (none fatal or in critical site). This study aimed to compare total healthcare cost between rivaroxaban and placebo, based on the EINSTEIN-EXT event rates.

Methods: Total healthcare cost was calculated as the sum of treatment and clinical event costs from a US managed care perspective. Treatment duration and event rates were obtained from the EINSTEIN-EXT study. Adjustment on treatment duration was made by assuming a 10% non-adherence rate. Drug costs were based on wholesale acquisition costs. Cost estimates for clinical events (i.e. recurrent deep vein thrombosis [DVT], recurrent pulmonary embolism, major bleeding, clinically relevant non-major bleeding) were determined from the literature. Results were examined over a ±20% range of each cost component and over 95% confidence intervals (CIs) of event rate differences in deterministic (one-way) and probabilistic sensitivity analyses (PSA).

Results: Total healthcare cost was $1,454 lower for rivaroxaban-treated (vs placebo-treated) patients in the base-case, with a lower clinical event cost fully offsetting drug cost. The cost savings of recurrent DVT alone (–$3,102) was greater than drug cost ($2,723). Total healthcare cost remained lower for rivaroxaban in the majority (73%) of PSA (cost difference [95% CI]?=?–$1,454 [–$2,396, $1,231]).

Limitations: This study was conducted over the 1-year observation period of the EINSTEIN-EXT trial, which limited “real-world” applicability and examination of long-term economic impact. Assumptions on drug and clinical event costs were US-based and, thus, not applicable to other healthcare systems.

Conclusions: Total healthcare costs were estimated to be lower for patients continuing rivaroxaban therapy compared to those receiving placebo in VTE patients who had completed 6–12 months of VTE treatment.     

中国农药施用与农业经济增长脱钩状态：时空特征与影响因素

[目的]明确农药施用与农业经济增长关联状态及其影响因素,为实现"控药减害增收"的目标提供借鉴。[方法]基于2005—2015年数据利用脱钩理论和对数平均分解指数法分解进行分析。[结果]中国农业经济增长伴生大量农药施用,仅少数省域表现出农药施用和农业经济增长扩张绝对脱钩的理想状态,东北西北部分省域农业经济增长则以更大幅度的农药投入增长为代价。中西部地区劳动力规模和技术进步效应是推动农药施用与农业经济增长脱钩的因素;东部地区种植规模变化、劳动力规模和技术进步因素均是推动农药施用和农业经济增长脱钩的因素;东北地区仅劳动力规模效应成为推动脱钩的力量。[结论]推动农药施用与农业经济增长脱钩需要强化农业科技的创新与普及,完善农业生产过程中的技术支撑,推动农业病虫害监测预警,加大对环境友好型低污染农药和肥料的推广度;构建农户施药的多重约束机制,完善农业病虫灾害保险减少农户对生产过程的风险感知,发挥农业合作社对农户施药行为的规制作用,完善产品分级认证和安全准入制度;通过农地合理流转和农业机械化等方式集约利用农业生产资源;因地制宜推动农药施用与农业经济增长脱钩,结合区域资源优势和农业发展阶段有针对性地设计对策措施。