普拉克索联合左旋多巴治疗帕金森病患者的临床效果

目的探讨普拉克索联合左旋多巴治疗帕金森病患者的临床效果。方法选取2017年3月至2020年3月辽宁省健康产业集团阜新矿总院收治的帕金森患者82例作为研究对象,随机分为对照组与观察组,各41例。对照组采取单一药物疗法(口服左旋多巴片),观察组采取联合用药方案(口服左旋多巴、普拉克索),比较两组治疗效果。结果用药后,观察组治疗有效率(95.12%)高于对照组(75.61%),差异有统计学意义(P<0.05);用药后,观察组谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽氧化物酶(GSH-Px)水平高于对照组,但行为能力评分(UPDRSⅠ)评分、日常生活能力评分(UPDRSⅡ)评分、运动能力评分(UPDRSⅢ)评分、运动并发症评分(UPDRSⅣ)评分低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异无统计学意义(P>0.05)。结论普拉克索+左旋多巴治疗帕金森疗效确切,可有效控制病情进展,改善病情,且安全可靠。

Effect of Pramipexole Combined with Levodopa in the Treatment of Parkinson’s Disease

Objective To explore the effect of pramipexole combined with levodopa in the treatment of Parkinson’s disease.Methods A total of 82 patients with Parkinson’s disease admitted to Fuxin Mining General Hospital,Health Industry Group in Liaoning Province from March 2017 to March 2020 were selected as the research objects and were randomly divided into a control group and an observation group,with 41 cases in each group.The control group was given single drug therapy(oral levodopa tablets),while the observation group was given combined medication(oral levodopa and pramipexole),and the therapeutic effects of the 2 groups were compared.Results After medication,the total effective rate of the observation group(95.12%)was higher than that of the control group(75.61%),and the difference was significant(P<0.05);the levels of GSH,SOD,CAT and GSH PX in the observation group were higher than those in the control group,but the UPDRS Ⅰ score,UPDRS Ⅱ score,UPDRS Ⅲ score and UPDRS Ⅳ score were lower than those of the control group,the difference was significant(P<0.05);the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).There was no significant difference(P>0.05).Conclusion Pramipexole plus levodopa is effective in the treatment of Parkinson’s disease,which can effectively control the progress of the disease and improve the condition,whihc safe and reliable.