Economic modelling of costs associated with outcomes reported for type 2 diabetes mellitus (T2DM) patients in the CANVAS and EMPA-REG cardiovascular outcomes trials

Aims: To model direct medical costs associated with reductions in cardiovascular disease (CVD) events in T2DM patients reported in the CANVAS and EMPA-REG trials, which assessed the cardiovascular safety of canagliflozin and empagliflozin, respectively.

Materials and methods: Costs were modeled from a US managed care organization (MCO) perspective for the CVD outcomes included in both trials: three-point major adverse cardiovascular event (MACE) and its components (cardiovascular-related death, nonfatal myocardial infarction, nonfatal stroke), as well as heart failure requiring hospitalization. The rate of CVD events averted (difference between study drug and placebo) was projected to the portion of an MCO T2DM population matching the respective trial’s inclusion criteria. A targeted literature search for paid amounts directly associated with each CVD event provided the unit costs, which were applied to the projected number of events averted, to calculate costs avoided per member per year (PMPY). One-way sensitivity analyses were performed on events averted, unit costs, and percentages of trial-applicable patients.

Results: Based on three-point MACE events averted, costs avoided PMPY of $6.17 (range: $1.27–$10.94) for CANVAS and $2.75 ($0.19–$4.83) for EMPA-REG were estimated. Costs avoided for individual components of MACE ranged from $0.77 to $3.84 PMPY for CANVAS and from -$0.97 (additional costs) to $1.54 for EMPA-REG. PMPY costs avoided for heart failure were $2.72 for CANVAS and $1.32 for EMPA-REG.

Limitations and conclusions: Models assumed independent, non-recurrent outcomes and were restricted to medical costs directly associated with the trial-reported events. The reductions in CVD events in T2DM patients reported for both CANVAS and EMPA-REG project to a positive cost avoidance for these events in an MCO population. The analysis did not include an assessment of the impact on total cost, as the costs associated with adverse events, drug utilization or other clinical outcomes were not examined.     

Mutual monitoring and corporate governance

Mutual monitoring in a well-structured authority system can mitigate the agency problem. I empirically examine whether the number two executive in a firm, if given authority, incentive, and channels for communication and influence, is able to monitor and constrain the potentially self-interested CEO. I find strong evidence that: (1) measures of the presence and extent of mutual monitoring from the No. 2 executive are positively related to future firm value (Tobin’s Q); (2) the beneficial effect is more pronounced for firms with stronger incentives for the No. 2 to monitor and with higher information asymmetry between the boards and the CEOs; and (3) mutual monitoring is a substitute for other governance mechanisms. The results suggest that mutual monitoring provides important checks and balances on CEO power.     

Remittance,Institutions and Investment Volatility Interactions: An Intercontinental Analysis

Generating massive investment for growth and development has been one of the main policy goals of most economies around the globe. Countries, most especially developing ones, are highly susceptible to investment volatility owing largely to the fragile nature of their economies as well as weaknesses in terms of dysfunctional institutions. Therefore, sound economic management suggests the need to better understand possible sources for mitigating the adverse effects of investment volatility. Remittances have been identified as important capital flows which do a good job of dousing macroeconomic volatilities. It is on this basis that the study sought to uncover the causal relationship between remittances and investment volatility via the intermediating role of institutions. Using a panel of 70 countries and the system Generalized Method of Moments (GMM) estimator, three insightful outcomes come to the fore. First, remittances played countercyclical roles across the estimated regressions. Second, institutional quality had no significant role in mitigating investment volatility and lastly, the interactive terms of both remittances and institutions significantly mitigated the negative impacts of investment volatility with the exception of the political component of the institutional architecture. Policy suggestions are drawn based on our results.     

浅析信息化工程的实现——以河北前进钢铁集团有限公司为例

文章通过借鉴国内外领先行业领域信息化建设的理论和已上线系统,结合前进钢铁公司(下文简称前钢公司)的实际情况,构建前钢公司总体信息化系统架构。并通过与周边计算机系统的合理功能分担与接口集成,实现前钢公司各个系统间信息实时传递,使企业的管理更加清晰、细致和严谨,从而进一步提升企业管理能力和产品质量,降低生产经营成本,满足对外快速响应、对内高效沟通的管理需求。     

The eruption of Airbnb in tourist cities: Comparing spatial patterns of hotels and peer-to-peer accommodation in Barcelona

In recent years, what has become known as collaborative consumption has undergone rapid expansion through peer-to-peer (P2P) platforms. In the field of tourism, a particularly notable example is that of Airbnb. This article analyses the spatial patterns of Airbnb in Barcelona and compares them with hotels and sightseeing spots. New sources of data, such as Airbnb listings and geolocated photographs are used. Analysis of bivariate spatial autocorrelation reveals a close spatial relationship between Airbnb and hotels, with a marked centre-periphery pattern, although Airbnb predominates around the city's main hotel axis and hotels predominate in some peripheral areas of the city. Another interesting finding is that Airbnb capitalises more on the advantages of proximity to the city's main tourist attractions than does the hotel sector. Multiple regression analysis shows that the factors explaining location are also different for hotels and Airbnb. Finally, it was possible to detect those parts of the city that have seen the greatest increase in pressure from tourism related to Airbnb's recent expansion.     

B2C电子零售商的业务模式影响因素

互联网经济的飞速发展,使得独立电子零售商的业务模式发生了较大的变化,B2C电子零售商的发展变化尤为明显,由自营销售式为主的独立电商逐渐呈现出自营销售与平台销售并存的方式,且平台销售的份额也在不断增长。本文主要就B2C电商选择平台销售还是自营销售模式提出一些观点,主要分析的是B2C电商在选择其业务模式时考虑的影响因素。     

The stained China miracle: Corruption,regulation, and firm performance

Regional corruptness in China has a positive effect on the profitability of private firms, but not that of state-owned firms. A natural experiment of exogenous trade policy change suggests that corruption may help private firms circumvent government regulation.     

Capital Controls,Global Liquidity Traps,and the International Policy Trilemma*

The zero bound on interest rates introduces a new dimension to the trilemma in international policy. The openness of the international financial market might render monetary policy ineffective, even within a system of fully flexible exchange rates, because shocks that lead to a liquidity trap in one country are propagated through financial markets to other countries. However, the effectiveness of monetary policy can be restored by the imposition of capital controls. We derive the optimal response of monetary policy to a global liquidity trap in the presence of capital controls. We show that, even though capital controls might facilitate effective monetary policy, capital controls are not generally desirable in terms of welfare.     

Interplay between ethanol and electric vehicles as low carbon mobility options for passengers in the municipality of São Paulo

The Brazilian cities as well as many of the large urban centers in the world continue to expand, increasing the demand for mobility and transport, while, at the same time, the same cities are investing in greenhouse gas (GHG) mitigation to avoid climate change. Brazil's urbanization rate increased from 26% in 1940 to almost 70% in 1980. During this period, the Brazilian population tripled and the urban population multiplied by seven. In 2010, the transport sector in São Paulo accounted for 71% of the total emissions released by the energy sector. Ethanol has been considered a fuel with less greenhouse gas emissions, when compared with fossil fuels. However, ethanol production would have to double to meet the expected demand. Electric vehicles (EVs) market is expanding around the world, and is also an option to reduce the transport emissions, if powered by clean electricity. To assess whether the adoption of EVs might bring more benefits than the current ethanol, we develop prospective scenarios supported by the Long-range Energy Alternatives Planning (LEAP) simulation tool, taking a bottom-up tank-to-wheel approach to consider the CO₂ emissions of car in São Paulo. The scenario considering a substitution of 25% of gasoline-powered cars by EV in 2030 showed a reduction in energy consumption and CO₂ emissions, around 15% and 26% respectively in that year in comparison with 2015. We discuss the interplay between ethanol and EV, also considering emission coefficients from life cycle analysis conducted in Brazil, and concluded EV will have higher positive impact on climate change mitigation than ethanol.