医工交叉创新成果转化中法律制度保障研究

医工交叉是医疗器械持续创新的基础动力,是我国医疗器械产业升级的关键。近年来,我国出台了一系列政策促进科技成果转化,但医工交叉领域具有周期长、多方参与、投资巨大等特点,导致其失败风险高并制约了科技成果转化的效率。本文通过分析医工交叉成果转化中存在的问题,从法律保障的视角提出能够促进科技成果转化的法律制度建议,从科研工作者权益保障、资金托管安全和知识产权收益等角度综合保障转化成果,促进我国医疗器械产业的可持续发展。     

Markets under the Microscope: Making Scientific Discoveries Valuable through Choreographed Contestations

This paper breaks new ground by revealing and conceptualizing the marketization of science as a process that transforms scientific discoveries and markets through a series of choreographed contestations: moments of valuation that occur when different social worlds collide. We follow a scientific discovery, from the moment it entered an incubator, to uncover how valuation practices and market devices enact and contest diverse social values (i.e., what is worth doing) to generate economic value (i.e., what is worth paying for) at the science‐market‐entrepreneurship nexus. In contrast with commercialization of science studies that focus on institutional arrangements, this study explicates the practices and devices used by multiple market actors to transform a scientific discovery into a marketable object. In so doing, we characterise choreographed contestations and the mechanisms through which they operate to explain how specific valuations are performed to work out innovative next steps that unfold the marketization of science.     

The impact of wearable devices on employee wellness programs: A study of hotel industry workers

Hospitality workplaces are particularly challenging contexts in which to implement wellness initiatives. The present study implemented a technology-based wellness intervention to improve various aspects of employee wellness in contemporary hotel workplaces. The participants were given a wearable device (Fitbit, used here as an innovative tool) in order to monitor their activity levels and sleep patterns over a 14-day period. Additionally, the participants provided researchers with food diaries in separate electronic form. Information regarding job satisfaction, job engagement, organizational citizenship behaviors, and intention to leave was obtained before and after the observation period. The results demonstrate an increase in physical activity, an increase in healthy food consumption, and a reduction in overall caloric intake. Furthermore, positive changes in employee engagement, job satisfaction, and organizational commitment were noted. Care should be exercised when implementing such interventions in order to ensure data privacy and positive employee relations.     

一种基于Radon变换的微表情识别算法

微表情是人们处在一些与平时生活环境不同的高强度环境下试图控制和掩饰的情感表现，也是一种不曾意识到的瞬时脸部表情,持续时间短，强度弱。为了提高其准确率，提出了基于Radon变换的微表情识别算法。首先，对数据库中的视频序列进行灰度归一化、尺寸归一化和二维主成分分析法（Two-dimensional Principal Component Analysis，2DPCA）降维预处理，使用光流法对降维后图像提取运动特征；然后使用Radon变换算法对光流图像进行处理，得到对应微表情的特征值和特征图像；最后使用支持向量机进行微表情分类识别。实验结果表明，使用Radon变换后得到的微表情特征图像得到了较好的识别效果，在微表情数据集CASME和CASMEⅡ上识别率分别为81.48%和82.17%，通过与选取的其他方法对比说明了该方法具有更好的识别性能。     

基于图像分析光学伪装效果的定量评价系统

针对传统的伪装效果评价容易受到试验条件、时间、经费等多方面限制的问题,提出了一种基于图像定量评价光学伪装效果的方法。利用AHP对颜色和形状进行权重的分析,得出颜色和形状的权重系数W1和W2,通过颜色评价系数对伪装图案与背景的图像颜色相似度进行定量评价,利用横纵比差值来对伪装图案与背景的图像形状相似度进行评价,最终得出基于图像分析光学伪装评价效果的定量评价系统。实验结果表明,该评价系统可实现对伪装图案与背景的颜色和形状相似程度的定量评价。     

Stage-gate process for life sciences and medical innovation investment

Life science innovation has led to significant improvements in clinical outcomes and has been a source of financial growth for individuals and institutions capable of performing appropriate investments in this sector. Several groups have developed methodologies to assist medical technology innovators in the design and development activities. Unfortunately, these tools have not aided the general investment community to profit from these enterprises. This situation has contributed to a general reduction in risk capital directed towards life sciences compared to other industries. We review the current investment practices in the life science sector and present a comprehensive stage-gate model that aims to captures this investment process. An analysis of best practices and in-depth interviews with 68 life sciences investors and entrepreneurs worldwide are used to support such model. A single case-control study comparing life science investment execution within two similar investment firms was conducted to evaluate feasibility in the implementation of these practices. The stage-gate model includes (I) General vision and investment strategy definition; (II) Venture search, screening and rapid pre-evaluation; (III) Due diligence and negotiation of terms; (IV) Portfolio management, evaluation, and exit. The difference in execution of investment and results from a post-performance Root Cause Analysis were consistent with a reduction in perceived risk from the case company trained with the proposed model compared to the control. This suggests that our developed model and process may be useful in encouraging life sciences investment via evidence-based evaluations.     

火力发电厂中基于光纤传感技术的火灾报警系统设计

针对国内外电厂对缆式线型感温的设计要求,突出了线型感温探测的重要性。从光纤感温探测的原理开始,对整套系统进行了结构性研究。主要研究了系统结构、探测光缆、控制器等组件。结合拉曼散射原理,剖析温度变化引起探测光缆的吸收和反吸收效应;强调了光学感温探测系统的应用优势和安装条件等。最后结合实体项目,分析对比了传统感温电缆和光学感温探测系统在实际工程应用中的优缺点,并提出了优化方案,以提高火灾报警系统的工作效率。     

基于光谱吸收的光纤瓦斯气体传感系统分析

根据瓦斯气体在一定波段对光有吸收的特性,通过对煤矿瓦斯气体吸收光谱的分析,研究了一种光纤传感瓦斯气体系统。     

医疗器械灭菌方法、灭菌工艺验证及无菌检查

文章阐述了湿热灭菌、干热灭菌、环氧乙烷灭菌、辐射灭菌、低温等离子体灭菌等5种医疗器械灭菌方法,并介绍了灭菌工艺验证和无菌检查方面的内容。     

输液生产后设备清洗残留物质监测方法的探讨

文章探讨大容量注射剂生产设备清洗后残留物质检查的方法,使用输液生产常用的原辅料及清洗剂,配制一定浓度,根据其化学性质分别采用测定pH值、电导率、旋光度、鉴别反应等方法,确定检测方法数据,从而控制残留物限度。